Astros vs. White Sox Prediction, Odds, Picks - June 10

Lance McCullers takes the mound for the Houston Astros on Tuesday against Miguel Vargas and the Chicago White Sox. First pitch is at 8:10 p.m. ET at Daikin Park. The favored Astros have -175 moneyline odds to win against the underdog White Sox, who are listed at +145. Houston is the favorite on the run line (-1.5 with +123 odds). A 7.5-run over/under has been set for this game.

Here is everything you need to know from a betting perspective on the Astros-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. White Sox Game Information & Odds

• When: Tuesday, June 10, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and CHSN

Astros vs. White Sox Prediction

• Score Prediction: Astros 5, White Sox 3
• Total Prediction: Over 7.5 runs
• Win Probabilities: Astros 58%, White Sox 42%

Astros vs. White Sox Betting Insights

• The Astros have won 25, or 56.8%, of the 44 games they've played as favorites this season.
• This season Houston has won three of its five games when favored by at least -175 on the moneyline.
• The bookmakers' moneyline implies a 63.6% chance of a victory for the Astros.
• The White Sox have won in 22, or 33.3%, of the 66 contests they have been named as odds-on underdogs this year.
• Chicago has a mark of 12-31 in contests where bookmakers favor it by +145 or worse on the moneyline.
• The White Sox have an implied victory probability of 40.8% according to the moneyline set by oddsmakers for this matchup.

Astros Recent Betting Performance

• The Astros went 5-3 across the eight games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to hit the over four times.
• The Astros' ATS record is 4-6-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• The Astros best hitter thus far this season is Jeremy Pena, who's hitting at a team-leading .316 clip along with nine homers and 32 RBI.
• Of all batters in MLB, Pena ranks 65th in home runs and 67th in RBI.
• Isaac Paredes has hit 14 home runs with 38 RBI. Both are team-highs.
• Paredes ranks 14th in home runs and 30th in RBI on the year.
• Jose Altuve is batting .261 with six doubles, nine home runs and 17 walks.
• Jake Meyers is hitting .302 with 11 doubles, a triple, three home runs and 19 walks.
• Meyers is riding a three-game hitting streak into this one. During his last five outings he is hitting .389 with a double and three walks.

Astros Team Props

White Sox Recent Betting Performance

• In 10 games as underdogs over the last 10 matchups, the White Sox have a record of 4-6.
• When it comes to hitting the over, the White Sox and their opponents are 5-5-0 in their last 10 games with a total.
• The White Sox have a record of 7-3-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Vargas leads the White Sox with nine home runs and runs batted in, driving in 29.
• Vargas' home run total puts him 65th in the majors, and he ranks 88th in RBI.
• Chase Meidroth is batting .299 with five doubles, two home runs and 21 walks.
• Meidroth ranks 257th in homers and 300th in RBI among all MLB batters this season.
• Andrew Benintendi is hitting .246 with six doubles, a triple, six home runs and 14 walks.
• Luis Robert is batting .177 with six doubles, five home runs and 25 walks.

White Sox Team Props

Astros vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Cleveland Guardians!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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