Astros vs. Padres Prediction, Odds, Picks - April 19

The Houston Astros and San Diego Padres will meet on Saturday at Daikin Park, at 7:10 p.m. ET, with Jose Carlos Altuve and Manny Machado among those expected to produce at the plate. The Astros are the favorite in this one, at -165, while the underdog Padres have +139 odds to upset. Houston (-1.5) is favored on the run line. The total is 9 runs for this matchup (with +101 odds to hit the over and -121 odds on the under).

Here is everything you need to know from a betting perspective on the Astros-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Astros Highlights | MLB on FOX

Check out the best moments between the San Diego Padres and the Houston Astros.

Astros vs. Padres Game Information & Odds

• When: Saturday, April 19, 2025 at 7:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: Fox Sports 1, SCHN, and SDPA

Astros vs. Padres Prediction

• Score Prediction: Padres 4, Astros 3
• Total Prediction: Under 9 runs
• Win Probabilities: Astros 53%, Padres 47%

Astros vs. Padres Betting Insights

• This season, the Astros have been favored 12 times and won six, or 50%, of those games.
• Houston has entered three games this season favored by -165 or more and is 1-2 in those contests.
• The implied probability of a win from the Astros, based on the moneyline, is 62.3%.
• The Padres have been chosen as underdogs in eight games this year and have walked away with the win four times (50%) in those games.
• Oddsmakers have given San Diego the worst odds of winning it has seen this season with a +139 moneyline listed for this contest.
• Bookmakers have implied with the moneyline set for this matchup that the Padres have a 41.8% chance of pulling out a win.

Astros Recent Betting Performance

• The Astros were favored on the moneyline in seven of their last 10 games, and they finished 4-3 in those matchups.
• In their last 10 matchups, the Astros and their opponents combined to go over the run total five times (all 10 of the games had set totals).
• The Astros have put together a 6-4-0 record against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Altuve has a team-high batting average of .321, and leads the Astros in home runs (three).
• Altuve is 60th in homers and 141st in RBI among all batters in baseball.
• Altuve carries a three-game hitting streak into this matchup. During his last five outings he is hitting .278 with a double and an RBI.
• Jeremy Pena has hit three home runs to lead his team.
• Among all MLB hitters, Pena ranks 60th in home runs and 141st in RBI.
• Pena enters this game looking for his 10th game in a row with a hit. During his last 10 outings he is batting .270 with two doubles, a home run, five walks and five RBI.
• Isaac Paredes leads the Astros with three home runs and 10 runs batted in.
• Jake Meyers is hitting .308 with three doubles and five walks.

Astros Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in three of their past 10 games and won one of those contests.
• When it comes to hitting the over, the Padres and their opponents are 5-5-0 in their last 10 games with a total.
• The Padres have a record of 7-3-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. leads the Padres with six home runs and 14 runs batted in, while posting a team-high batting average of .342.
• In all of the majors, Tatis ranks eighth in home runs and 22nd in RBI.
• Tatis has collected a hit in seven straight games. In his last 10 outings he is hitting .282 with five home runs, seven walks and eight RBI.
• Machado has eight doubles, two home runs and eight walks while batting .307.
• Among all major league hitters, Machado is 106th in home runs and 94th in RBI.
• Luis Sangel (Reveron) Arraez has three doubles, three home runs and three walks while hitting .294.
• Xander Bogaerts is hitting .257 with seven doubles and 10 walks.

Padres Team Props

Padres vs. Astros Highlights | MLB on FOX

Check out the best moments between the San Diego Padres and the Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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