Astros vs. Cubs Prediction, Odds, Picks - June 28

Cam Smith and the Houston Astros will see Colin Rea on the mound for the Chicago Cubs in the second game of a three-game series, Saturday at 7:15 p.m. ET. Bookmakers list the Astros as -115 moneyline favorites, while giving the underdog Cubs -105 moneyline odds. Chicago is a 1.5-run favorite (at +156 odds). The over/under for the contest is listed at 8.5 runs.

Here is everything you need from a betting perspective on the Astros-Cubs game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Astros Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs and Houston Astros.

Astros vs. Cubs Game Information & Odds

• When: Saturday, June 28, 2025 at 7:15 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: FOX

Astros vs. Cubs Prediction

• Score Prediction: Astros 5, Cubs 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Astros 52%, Cubs 48%

Astros vs. Cubs Betting Insights

• The Astros have won 35, or 61.4%, of the 57 games they've played as favorites this season.
• Houston has entered 52 games this season favored by -115 or more and is 32-20 in those contests.
• The Astros have a 53.5% chance to win this game based on the implied probability of the moneyline.
• The Cubs have won in nine, or 36%, of the 25 contests they have been named as odds-on underdogs this year.
• This season, Chicago has come away with a win eight times in 21 chances when named as an underdog of at least -105 or longer on the moneyline.
• The moneyline set for this matchup implies the Cubs have a 51.2% chance of coming away with a victory in the contest.

Astros Recent Betting Performance

• The Astros went 7-1 over the eight games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings -- all had a set run total -- the Astros and their opponents combined to go over the total five times.
• The Astros have gone 4-6-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• The Astros best hitter thus far this season is Jeremy Pena, who's hitting at a team-leading .322 rate along with 11 homers and 40 RBI.
• Of all hitters in MLB, Pena's home run total ranks him 66th, and his RBI tally puts him 66th.
• Isaac Paredes has shown his power as he leads his team with 16 home runs and 45 RBI.
• Paredes is 23rd in home runs and 37th in RBI in the bigs.
• Jose Altuve is batting .263 with 10 doubles, 12 home runs and 27 walks.
• Altuve has at least one base hit in two straight games. In his last five games he is batting .167 with three walks.
• Jake Meyers is hitting .307 with 13 doubles, a triple, three home runs and 24 walks.
• Meyers is riding a three-game hitting streak into this one. During his last five outings he is hitting .294 with a walk and an RBI.

Astros Team Props

Cubs Recent Betting Performance

• The Cubs have been underdogs twice in the last 10 games and lost both contests.
• In their last 10 games with a total, the Cubs and their opponents have failed to hit the over three times.
• The Cubs have four wins against the spread in their last 10 chances.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker is hitting .283 with 16 doubles, four triples, 16 home runs and 53 walks, while getting on base at a rate of .391.
• Tucker ranks 23rd in homers and 28th in RBI among all batters in MLB.
• Pete Crow-Armstrong has shown off his power as he paces his team with 21 home runs.
• Crow-Armstrong ranks seventh in homers and ninth in RBI among all major league hitters this season.
• Seiya Suzuki has been a significant run producer for the Cubs with 21 home runs and 67 runs batted in.
• Nico Hoerner leads the team in batting average with a high-water mark of .294.

Cubs Team Props

Cubs vs. Astros Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs and Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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