Astros vs. Angels Prediction, Odds, Picks - September 28

Mike Trout and the Los Angeles Angels will try to take down Jose Altuve and the Houston Astros when the teams meet on Sunday at 3:07 p.m. ET. The favored Astros have -143 moneyline odds against the underdog Angels, who are listed at +121. Houston is the favorite on the run line (-1.5 with +113 odds). The total for the contest is listed at 9 runs.

Take a look at everything you need to know from a betting perspective on the Astros-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Athletics Highlights | MLB on FOX

Check out the best highlights between the Houston Astros and Athletics.

Astros vs. Angels Game Information & Odds

• When: Sunday, September 28, 2025 at 3:07 p.m. ET
• Where: Angel Stadium in Anaheim, California
• How to watch on TV: FDSW and SCHN

Astros vs. Angels Prediction

• Score Prediction: Astros 7, Angels 6
• Total Prediction: Over 9 runs
• Win Probabilities: Astros 51%, Angels 49%

Astros vs. Angels Betting Insights

• The Astros have entered the game as favorites 104 times this season and won 54, or 51.9%, of those games.
• Houston is 23-19 this season when entering a game favored by -143 or more on the moneyline.
• The Astros have a 58.8% chance to win this game based on the implied probability of the moneyline.
• The Angels have been underdogs in 122 games this season and have come away with the win 53 times (43.4%) in those contests.
• This season, Los Angeles has been victorious 33 times in 77 chances when named as an underdog of at least +121 or worse on the moneyline.
• The Angels have an implied victory probability of 45.2% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros went 2-4 over the six games they were favored on the moneyline in their last 10 matchups.
• In their last 10 matchups, the Astros and their opponents combined to hit the over on the run total four times (all 10 games had set totals).
• The Astros have put together a 4-6-0 record against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Altuve is batting .265 with 24 doubles, a triple, 26 home runs and 55 walks.
• Altuve's home runs place him 43rd in MLB, and he is 61st in RBI.
• Jeremy Pena is batting .304 to lead his team.
• Pena is 111th in homers and 117th in RBI on the season.
• Christian Walker paces the Astros in home runs (27) and runs batted in (88).
• Walker has at least one base hit in six straight games. During his last 10 outings he is batting .243 with a double, four home runs and seven RBIs.
• Yainer Diaz has 25 doubles, a triple, 19 home runs and 20 walks while batting .255.
• Diaz is riding a two-game hitting streak into this one. In his last five games he is hitting .235 with two doubles.

Astros Team Props

Angels Recent Betting Performance

• The Angels have played as underdogs in eight of their past 10 games and won two of those contests.
• When it comes to hitting the over, the Angels and their opponents are 4-6-0 in their last 10 games with a total.
• The Angels have three wins against the spread in their last 10 chances.

Angels Recent Stats

Angels Player Insights

• Taylor Ward has driven in the most runs for the Angels with 103 runs batted in.
• Ward's home run total puts him 10th in MLB, and he is 11th in RBI.
• Jo Adell has shown off his power as he paces his team with 37 home runs.
• Adell ranks ninth overall in home runs and 17th in RBI this season.
• Nolan Schanuel leads the Angels' lineup with a .264 batting average.
• Trout is hitting .231 with 14 doubles, a triple, 25 home runs and 87 walks.

Angels Team Props

Astros vs. Athletics Highlights | MLB on FOX

Check out the best highlights between the Houston Astros and Athletics.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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