Astros vs. Angels Prediction, Odds, Picks - September 27

Jose Altuve and the Houston Astros take the field on Saturday at Angel Stadium against Caden Dana, who is starting for the Los Angeles Angels. First pitch is at 9:38 p.m. ET. The favored Astros have -146 moneyline odds against the underdog Angels, who are listed at +122. Houston is the favorite on the run line (-1.5 with +114 odds). The over/under for the matchup is set at 9 runs.

Here's everything you need to know from a betting perspective on the Astros-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Royals vs. Angels Highlights | MLB on FOX

Check out the best moments between the Kansas City Royals and Los Angeles Angels.

Astros vs. Angels Game Information & Odds

• When: Saturday, September 27, 2025 at 9:38 p.m. ET
• Where: Angel Stadium in Anaheim, California
• How to watch on TV: FDSW and SCHN

Astros vs. Angels Prediction

• Score Prediction: Astros 7, Angels 6
• Total Prediction: Over 9 runs
• Win Probabilities: Astros 50%, Angels 50%

Astros vs. Angels Betting Insights

• The Astros have been favorites in 103 games this season and won 53 (51.5%) of those contests.
• Houston is 21-16 this season when entering a game favored by -146 or more on the moneyline.
• The Astros have a 59.3% chance to win this game based on the implied probability of the moneyline.
• The Angels have won in 53, or 43.8%, of the 121 contests they have been named as odds-on underdogs this year.
• This season, Los Angeles has been victorious 32 times in 74 chances when named as an underdog of at least +122 or longer on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Angels have a 45% chance of pulling out a win.

Astros Recent Betting Performance

• The Astros played as the moneyline favorite in six of their last 10 games, and they went 2-4 in those matchups.
• Over their last 10 matchups (all had set totals), the Astros combined with their opponents to hit the over on the total five times.
• The Astros have put together a 4-6-0 record against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Altuve leads the Astros with 26 round-trippers on the year. He's also hitting .264 with 77 RBI.
• Among all batters in baseball, Altuve ranks 42nd in home runs and 59th in RBI.
• Jeremy Pena is hitting .304 to lead his team.
• Pena is 111th in home runs and 117th in RBI on the year.
• Yainer Diaz has 25 doubles, a triple, 19 home runs and 20 walks while hitting .255.
• Carlos Correa has 29 doubles, 13 home runs and 45 walks while batting .276.
• Correa has recorded at least one hit in three straight games. During his last five outings he is hitting .294 with two doubles, four walks and two RBIs.

Astros Team Props

Angels Recent Betting Performance

• In eight games as underdogs over the last 10 matchups, the Angels have a record of 2-6.
• When it comes to hitting the over, the Angels and their opponents are 5-5-0 in their last 10 games with a total.
• The Angels have a record of 3-7-0 ATS over their last 10 games.

Angels Recent Stats

Angels Player Insights

• Taylor Ward has driven in a team-leading 103 runs batted in.
• Ward's home run total places him 10th in MLB, and he ranks 11th in RBI.
• Nolan Schanuel is batting .264 to lead the lineup.
• Among all major league hitters, Schanuel is 175th in home runs and 153rd in RBI.
• Jo Adell has 37 home runs, tops in the clubhouse.
• Mike Trout is batting .230 with 14 doubles, a triple, 25 home runs and 86 walks.

Angels Team Props

Royals vs. Angels Highlights | MLB on FOX

Check out the best moments between the Kansas City Royals and Los Angeles Angels.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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