Angels vs. Astros Prediction, Odds, Picks - June 22

Nolan Schanuel and Jeremy Pena will be among the stars on display when the Los Angeles Angels play the Houston Astros on Sunday at 4:07 p.m. ET, at Angel Stadium. The Angels are favored in this one, at -125, while the underdog Astros have +104 odds to upset. Los Angeles (-1.5) is favored on the run line. An 8-run total has been set in this game.

Check out everything you need from a betting perspective on the Angels-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Angels vs. Astros Game Information & Odds

• When: Sunday, June 22, 2025 at 4:07 p.m. ET
• Where: Angel Stadium in Anaheim, California
• How to watch on TV: FDSW and SCHN

Angels vs. Astros Prediction

• Score Prediction: Astros 5, Angels 4
• Total Prediction: Over 8 runs
• Win Probabilities: Angels 51%, Astros 49%

Angels vs. Astros Betting Insights

• This season, the Angels have won nine out of the 15 games, or 60%, in which they've been favored.
• Los Angeles has a record of 8-5 in games when oddsmakers favor them by at least -125 on the moneyline.
• The moneyline for this contest implies a 55.6% chance of a victory for the Angels.
• The Astros have been underdogs in 24 games this season and have come away with the win 13 times (54.2%) in those contests.
• This season, Houston has come away with a win seven times in 14 chances when named as an underdog of at least +104 or longer on the moneyline.
• The moneyline set for this matchup implies the Astros have a 49% chance of coming away with a victory in the contest.

Angels Recent Betting Performance

• Over the last 10 games, the Angels have been named the moneyline favorite by oddsmakers just twice, and they won both games.
• Over their last 10 matchups, the Angels and their opponents combined to hit the over four times (all 10 of the games had set totals).
• The Angels have gone 6-4-0 against the spread over their past 10 games.

Angels Recent Stats

Angels Player Insights

• Schanuel paces the Angels with a .277 batting average.
• Schanuel's home runs put him 186th in MLB, and he is 147th in RBI.
• Taylor Ward's 19 home runs and 52 RBI both lead his team.
• Ward is ninth in home runs and 13th in RBI among all MLB hitters this year.
• Ward has three games in a row with at least one hit. In his last five games he is batting .200 with a double, a home run, two walks and five RBIs.
• Zach Neto is hitting .267 with 15 doubles, a triple, 10 home runs and 11 walks.
• Jo Adell is batting .223 with seven doubles, 16 home runs and 15 walks.
• Adell is riding a four-game hitting streak into this one. In his last five games he is hitting .235 with three home runs, three walks and four RBIs.

Angels Team Props

Astros Recent Betting Performance

• The Astros have played as underdogs in three of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Astros and their opponents have combined to hit the over four times.
• Over their last 10 games, the Astros are 4-6-0 against the spread.

Astros Recent Stats

Astros Player Insights

• Pena leads the Astros with a .324 batting average.
• Among all batters in the majors, Pena's home run total ranks 69th and his RBI tally is 62nd.
• Isaac Paredes has hit 16 home runs with 45 runs batted in, leading the team in both categories.
• Paredes is currently 15th in home runs and 28th in RBI in the big leagues.
• Jose Altuve is batting .269 with 10 doubles, 12 home runs and 24 walks.
• Jake Meyers is batting .307 with 13 doubles, a triple, three home runs and 23 walks.

Astros Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Angels

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