Virginia Tech vs. Old Dominion Prediction, Odds, Picks - September 13, 2025

Updated Sep. 13, 2025 3:04 p.m. ET

Data Skrive

Oddsmakers give the Virginia Tech Hokies (0-2) the advantage on Saturday, September 13, 2025 against the Old Dominion Monarchs (1-1). Virginia Tech is favored by 5.5 points. A 51.5-point over/under is set for the contest.

The Hokies lost to the Vanderbilt Commodores, 44-20, in their most recent contest. Last time around, the Monarchs defeated the North Carolina Central Eagles, with 54-6 being the final score.

Keep up with college football all season on FOX Sports.

Virginia Tech vs. Old Dominion Game Information & Odds

When: Saturday, September 13, 2025 at 7 p.m. ET
Location: Lane Stadium in Blacksburg, Virginia
TV: ACC Network
Live Box Score on FOX Sports

Virginia Tech vs Old Dominion Betting Information updated as of September 13, 2025, 1:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Virginia Tech	-5.5 (-111)	-222	+182	51.5	-108	-112

Virginia Tech vs. Old Dominion Prediction

Pick ATS: Old Dominion (+5.5)
Pick OU: Under (51.5)
Prediction: Virginia Tech 25, Old Dominion 20

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Tech Hokies vs. the Old Dominion Monarchs game on FOX Sports!

Virginia Tech vs. Old Dominion Betting Insights

Per the spread and over/under, the implied score for the matchup is Hokies 28, Monarchs 23.
The Hokies have a 68.9% chance to collect the win in this meeting based on the moneyline's implied probability. The Monarchs hold a 35.5% implied probability.
Virginia Tech is winless against the spread this season (0-2-0).
Old Dominion has won two games against the spread this year.

Virginia Tech vs. Old Dominion: Head-to-Head

In their last three head-to-head matchups, Virginia Tech has defeated Old Dominion two times.
The Hokies carry a 2-1 record ATS in those games, while the two teams have gone over the point total on two occasions.
Old Dominion has been outscored by 36 points in its last three tilts against Virginia Tech.

Virginia Tech vs. Old Dominion: 2025 Stats Comparison

	Virginia Tech	Old Dominion
Off. Points per Game (Rank)	15.5 (118)	34 (57)
Def. Points per Game (Rank)	34 (110)	16.5 (55)
Turnovers Allowed (Rank)	3 (83)	4 (108)
Turnovers Forced (Rank)	2 (64)	4 (19)

Virginia Tech 2025 Key Players

Name	Position	Stats
Kyron Drones	QB	355 YDS (50%) / 1 TD / 2 INT 62 RUSH YDS / 1 RUSH TD / 31 RUSH YPG
Donavon Greene	WR	4 REC / 116 YDS / 0 TD / 58 YPG
Marcellous Hawkins	RB	87 YDS / 0 TD / 43.5 YPG / 3.8 YPC
Ayden Greene	WR	7 REC / 81 YDS / 0 TD / 40.5 YPG
Quentin Reddish	DB	11 TKL / 0 TFL / 1 INT / 1 PD
Caleb Woodson	LB	15 TKL / 1 TFL
Michael Short	LB	16 TKL / 1 TFL
Elhadj Fall	DL	1 TKL / 0 TFL / 1 SACK

Old Dominion 2025 Key Players

Name	Position	Stats
Colton Joseph	QB	353 YDS (65.2%) / 3 TD / 3 INT 231 RUSH YDS / 3 RUSH TD / 115.5 RUSH YPG
Trequan Jones	RB	163 YDS / 3 TD / 163 YPG / 32.6 YPC
Ja'Cory Thomas	WR	8 REC / 110 YDS / 1 TD / 55 YPG
Na'eem Abdul-Rahim Gladding	WR	7 REC / 69 YDS / 1 TD / 34.5 YPG
Jeremy Mack Jr.	LB	4 TKL / 2 TFL / 2 SACK
Nickendre Stiger	DB	6 TKL / 1 TFL
Jahleel Culbreath	LB	6 TKL / 1 TFL / 1 SACK
Jerome Carter	DB	5 TKL / 0 TFL / 1 INT / 1 PD