Vanderbilt vs. LSU Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 9:04 a.m. ET

FOX Sports

The No. 17 Vanderbilt Commodores (5-1) will test their 23rd-ranked rushing attack against the No. 10 LSU Tigers (5-1), who have the No. 116 rush defense in the nation, on Saturday, October 18, 2025. The Commodores are favored by just 2 points in the game. A 47.5-point over/under is set for the contest.

The Commodores lost against the Alabama Crimson Tide in their most recent game, 30-14. The Tigers' last game was versus the South Carolina Gamecocks, and they won by a score of 20-10.

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Vanderbilt vs. LSU Game Information & Odds

When: Saturday, October 18, 2025 at 12 p.m. ET
Location: FirstBank Stadium in Nashville, Tennessee
TV: ABC
Live Box Score on FOX Sports

Vanderbilt vs LSU Betting Information updated as of October 18, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Vanderbilt	-2 (-110)	-123	+103	47.5	-112	-108

Vanderbilt vs. LSU Prediction

Pick ATS: Vanderbilt (-2)
Pick OU: Over (47.5)
Prediction: Vanderbilt 28, LSU 20

Predictions are made by the Data Skrive betting model.

Learn more about the Vanderbilt Commodores vs. the LSU Tigers game on FOX Sports!

Vanderbilt vs. LSU Betting Insights

Per the spread and over/under, the implied score for the tilt is Commodores 25, Tigers 23.
The Commodores have a 55.2% chance to claim victory in this meeting per the moneyline's implied probability. The Tigers have a 49.3% implied probability.
Vanderbilt has put together a 4-2-0 record against the spread this season.
LSU is 3-3-0 ATS this season.

Vanderbilt vs. LSU: 2025 Stats Comparison

	Vanderbilt	LSU
Off. Points per Game (Rank)	43.2 (7)	25.8 (93)
Def. Points per Game (Rank)	19.3 (32)	11.8 (5)
Turnovers Allowed (Rank)	6 (35)	8 (76)
Turnovers Forced (Rank)	10 (30)	10 (30)

Vanderbilt 2025 Key Players

Name	Position	Stats
Diego Pavia	QB	1,409 YDS (71.4%) / 14 TD / 4 INT 352 RUSH YDS / 2 RUSH TD / 58.7 RUSH YPG
Sedrick Alexander	RB	319 YDS / 5 TD / 53.2 YPG / 6.4 YPC 8 REC / 89 REC YDS / 4 REC TD / 14.8 REC YPG
Junior Sherrill	WR	23 REC / 274 YDS / 5 TD / 45.7 YPG
Makhilyn Young	RB	211 YDS / 4 TD / 35.2 YPG / 10 YPC 5 REC / 33 REC YDS / 0 REC TD / 11 REC YPG
Miles Capers	DL	16 TKL / 5 TFL / 4.5 SACK
CJ Heard	DB	27 TKL / 1 TFL / 1 SACK / 1 INT
Nicholas Rinaldi	LB	17 TKL / 4 TFL / 2 SACK
Khordae Sydnor	DL	12 TKL / 4 TFL / 2.5 SACK

LSU 2025 Key Players

Name	Position	Stats
Garrett Nussmeier	QB	1,411 YDS (66.2%) / 9 TD / 5 INT 13 RUSH YDS / 1 RUSH TD / 2.2 RUSH YPG
Caden Durham	RB	283 YDS / 2 TD / 56.6 YPG / 4.2 YPC 9 REC / 56 REC YDS / 0 REC TD / 11.2 REC YPG
Zavion Thomas	WR	15 REC / 184 YDS / 2 TD / 30.7 YPG
Barion Brown	WR	27 REC / 261 YDS / 1 TD / 43.5 YPG
Tamarcus Cooley	DB	25 TKL / 0 TFL / 2 INT / 2 PD
West Weeks	LB	33 TKL / 1 TFL / 0.5 SACK
Harold Perkins	LB	21 TKL / 2 TFL / 2 SACK
Adari Haulcy	DB	23 TKL / 0 TFL / 1 INT / 1 PD