USC vs. Purdue Prediction, Odds, Picks - September 13, 2025

Updated Sep. 13, 2025 3:04 p.m. ET

Data Skrive

The Purdue Boilermakers (2-0) are 20.5-point underdogs in a home Big Ten matchup with the USC Trojans (2-0) on Saturday, September 13, 2025 at Ross-Ade Stadium. The over/under is set at 59.5 for the game.

The Trojans beat the Georgia Southern Eagles, 59-20, in their most recent contest. The Boilermakers beat the Southern Illinois Salukis, 34-17, in their last contest.

Keep up with college football all season on FOX Sports.

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USC vs. Purdue Game Information & Odds

When: Saturday, September 13, 2025 at 3:30 p.m. ET
Location: Ross-Ade Stadium in West Lafayette, Indiana
TV: CBS
Live Box Score on FOX Sports

USC vs Purdue Betting Information updated as of September 13, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-20.5 (-111)	-1538	+862	59.5	-108	-112

USC vs. Purdue Prediction

Pick ATS: Purdue (+20.5)
Pick OU: Under (59.5)
Prediction: USC 32, Purdue 25

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Purdue Boilermakers game on FOX Sports!

USC vs. Purdue Betting Insights

Per the spread and over/under, the implied score for the matchup is Trojans 40, Boilermakers 20.
The Trojans have a 93.9% chance to claim victory in this contest per the moneyline's implied probability. The Boilermakers hold a 10.4% implied probability.
USC has a record of 2-0-0 against the spread this season.
Purdue has a record of 1-1-0 against the spread this season.

USC vs. Purdue: 2025 Stats Comparison

	USC	Purdue
Off. Points per Game (Rank)	66 (2)	32.5 (59)
Def. Points per Game (Rank)	16.5 (55)	8.5 (13)
Turnovers Allowed (Rank)	2 (54)	1 (22)
Turnovers Forced (Rank)	4 (19)	0 (126)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	707 YDS (73.8%) / 6 TD / 0 INT 14 RUSH YDS / 1 RUSH TD / 7 RUSH YPG
Makai Lemon	WR	11 REC / 248 YDS / 2 TD / 124 YPG
Eli Sanders	RB	85 YDS / 2 TD / 42.5 YPG / 6.5 YPC 3 REC / 86 REC YDS / 1 REC TD / 43 REC YPG
Waymond Jordan	RB	209 YDS / 2 TD / 104.5 YPG / 10 YPC
Anthony Lucas	DL	2 TKL / 2 TFL / 2 SACK
Braylan Shelby	DL	2 TKL / 2 TFL / 2 SACK
Kameryn Fountain	DL	2 TKL / 2 TFL / 2 SACK
Eric Gentry	LB	2 TKL / 1 TFL / 1 SACK

Purdue 2025 Key Players

Name	Position	Stats
Ryan Browne	QB	481 YDS (65.3%) / 4 TD / 1 INT 55 RUSH YDS / 1 RUSH TD / 27.5 RUSH YPG
Devin Mockobee	RB	185 YDS / 3 TD / 92.5 YPG / 4 YPC 4 REC / 66 REC YDS / 0 REC TD / 33 REC YPG
Arhmad Branch	WR	5 REC / 132 YDS / 2 TD / 66 YPG
Michael Jackson III	WR	7 REC / 79 YDS / 1 TD / 39.5 YPG
CJ Nunnally	DL	3 TKL / 2 TFL / 2 SACK
Charles Correa	LB	5 TKL / 2 TFL / 1 SACK
Mani Powell	LB	4 TKL / 1 TFL / 1 SACK
Breylon Charles	DL	3 TKL / 1 TFL / 1 SACK