USC vs. Nebraska Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 3:04 p.m. ET

Data Skrive

The No. 23 USC Trojans (5-2), who have college football's first-ranked passing offense, square off against the Nebraska Cornhuskers (6-2) and their 25th-ranked passing attack on Saturday, November 1, 2025. The Trojans are 4.5-point favorites. The point total is set at 59.5.

The Trojans' last contest was against the Notre Dame Fighting Irish, and they lost by a score of 34-24. Facing the Northwestern Wildcats in their most recent contest, the Cornhuskers won 28-21.

Keep up with college football all season on FOX Sports.

USC vs. Nebraska Game Information & Odds

When: Saturday, November 1, 2025 at 7:30 p.m. ET
Location: Memorial Stadium (Lincoln, NE) in Lincoln, Nebraska
TV: NBC
Live Box Score on FOX Sports

USC vs Nebraska Betting Information updated as of November 1, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-4.5 (-110)	-195	+162	59.5	-108	-112

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USC vs. Nebraska Prediction

Pick ATS: USC (-4.5)
Pick OU: Under (59.5)
Prediction: USC 32, Nebraska 27

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Nebraska Cornhuskers game on FOX Sports!

USC vs. Nebraska Betting Insights

Based on the spread and over/under, the implied score for the game is Trojans 32, Cornhuskers 28.
The Trojans have a 66.1% chance to win this game based on the moneyline's implied probability. The Cornhuskers hold a 38.2% implied probability.
USC has put together a 4-3-0 record against the spread this season.
Nebraska has a record of just 2-5-1 against the spread this year.

USC vs. Nebraska: 2025 Stats Comparison

	USC	Nebraska
Off. Points per Game (Rank)	42.4 (13)	35 (23)
Def. Points per Game (Rank)	23.1 (42)	19.6 (37)
Turnovers Allowed (Rank)	10 (68)	8 (37)
Turnovers Forced (Rank)	12 (32)	11 (40)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	2,180 YDS (68.1%) / 15 TD / 4 INT 41 RUSH YDS / 4 RUSH TD / 5.9 RUSH YPG
Makai Lemon	WR	48 REC / 758 YDS / 6 TD / 108.3 YPG
Waymond Jordan	RB	576 YDS / 5 TD / 96 YPG / 6.5 YPC
Ja'Kobi Lane	WR	24 REC / 424 YDS / 3 TD / 70.7 YPG
Eric Gentry	LB	30 TKL / 4 TFL / 3 SACK
Bishop Fitzgerald	DB	24 TKL / 1 TFL / 1 SACK / 5 INT
Braylan Shelby	DL	9 TKL / 3 TFL / 3.5 SACK / 1 INT
Devan Thompkins	DL	12 TKL / 2 TFL / 3 SACK

Nebraska 2025 Key Players

Name	Position	Stats
Emmett Johnson	RB	837 YDS / 9 TD / 104.6 YPG / 5.7 YPC 31 REC / 182 REC YDS / 1 REC TD / 22.8 REC YPG
Dylan Raiola	QB	1,911 YDS (72.8%) / 17 TD / 6 INT
Nyziah Hunter	WR	33 REC / 525 YDS / 5 TD / 65.6 YPG
Jacory Barney Jr.	WR	30 REC / 378 YDS / 3 TD / 47.3 YPG
Javin Wright	LB	51 TKL / 5 TFL / 0.5 SACK / 1 INT
DeShon Singleton	DB	33 TKL / 0 TFL / 2 INT / 2 PD
Vincent Shavers Jr.	LB	29 TKL / 4 TFL
Williams Nwaneri	DL	21 TKL / 2 TFL / 1.5 SACK