USC vs. Michigan State Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 9:04 p.m. ET

Data Skrive

Oddsmakers heavily favor the No. 25 USC Trojans (3-0) when they host the Michigan State Spartans (3-0) on Saturday, September 20, 2025 in a matchup between Big Ten foes at Los Angeles Memorial Coliseum. USC is favored by 18.5 points. The over/under is set at 55.5.

In their last game, the Trojans won versus the Purdue Boilermakers, 33-17. Last time around, the Spartans defeated the Youngstown State Penguins, with 41-24 being the final score.

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USC vs. Michigan State Game Information & Odds

When: Saturday, September 20, 2025 at 11 p.m. ET
Location: Los Angeles Memorial Coliseum in Los Angeles, California
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

USC vs Michigan State Betting Information updated as of September 20, 2025, 8:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-18.5 (-117)	-1010	+646	55.5	-108	-112

USC vs. Michigan State Prediction

Pick ATS: Michigan State (+18.5)
Pick OU: Over (55.5)
Prediction: USC 38, Michigan State 26

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Michigan State Spartans game on FOX Sports!

USC vs. Michigan State Betting Insights

Based on the spread and over/under, the implied score for the game is Trojans 37, Spartans 18.
The Trojans have a 91.0% chance to collect the win in this contest per the moneyline's implied probability. The Spartans have a 13.4% implied probability.
USC has won two games against the spread this season.
Michigan State has not won against the spread this season in three games with a spread.

USC vs. Michigan State: 2025 Stats Comparison

	USC	Michigan State
Off. Points per Game (Rank)	55 (9)	35.3 (57)
Def. Points per Game (Rank)	16.7 (37)	23.3 (66)
Turnovers Allowed (Rank)	2 (23)	4 (67)
Turnovers Forced (Rank)	7 (10)	3 (77)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	989 YDS (68.6%) / 6 TD / 0 INT 24 RUSH YDS / 2 RUSH TD / 8 RUSH YPG
Waymond Jordan	RB	286 YDS / 3 TD / 95.3 YPG / 7.3 YPC
Makai Lemon	WR	16 REC / 311 YDS / 2 TD / 103.7 YPG
Eli Sanders	RB	160 YDS / 2 TD / 53.3 YPG / 7 YPC 4 REC / 88 REC YDS / 1 REC TD / 29.3 REC YPG
Eric Gentry	LB	10 TKL / 2 TFL / 3 SACK
Bishop Fitzgerald	DB	5 TKL / 0 TFL / 3 INT / 3 PD
Kameryn Fountain	DL	5 TKL / 3 TFL / 2.5 SACK
Anthony Lucas	DL	4 TKL / 2 TFL / 2 SACK

Michigan State 2025 Key Players

Name	Position	Stats
Aidan Chiles	QB	656 YDS (71.6%) / 6 TD / 1 INT 123 RUSH YDS / 1 RUSH TD / 41 RUSH YPG
Nick Marsh	WR	16 REC / 194 YDS / 3 TD / 64.7 YPG
Makhi Frazier	RB	206 YDS / 2 TD / 68.7 YPG / 4.8 YPC
Brandon Tullis	RB	112 YDS / 2 TD / 37.3 YPG / 6.2 YPC
Jordan Hall	LB	26 TKL / 3 TFL / 2 SACK
Wayne Matthews III	LB	23 TKL / 0 TFL / 1 INT / 1 PD
Malik Spencer	DB	11 TKL / 1 TFL / 1 SACK
Armorion Smith	DB	9 TKL / 0 TFL / 1 INT / 1 PD