TCU vs. Colorado Prediction, Odds, Picks - October 4, 2025

Updated Oct. 4, 2025 3:04 p.m. ET

Data Skrive

Big 12 foes square off when the TCU Horned Frogs (3-1) host the Colorado Buffaloes (2-3) on Saturday, October 4, 2025 at Amon G. Carter Stadium. TCU is favored by 13.5 points. The total is 57.5 points for this game.

Last time out, the Horned Frogs fell to the Arizona State Sun Devils, with 27-24 being the final score. The Buffaloes lost against the BYU Cougars in their last game, 24-21.

Keep up with college football all season on FOX Sports.

TCU vs. Colorado Game Information & Odds

When: Saturday, October 4, 2025 at 7:30 p.m. ET
Location: Amon G. Carter Stadium in Fort Worth, Texas
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

TCU vs Colorado Betting Information updated as of October 4, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
TCU	-13.5 (-111)	-549	+405	57.5	-110	-110

TCU vs. Colorado Prediction

Pick ATS: Colorado (+13.5)
Pick OU: Under (57.5)
Prediction: TCU 31, Colorado 22

Predictions are made by the Data Skrive betting model.

Learn more about the TCU Horned Frogs vs. the Colorado Buffaloes game on FOX Sports!

TCU vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the game is Horned Frogs 36, Buffaloes 22.
The Horned Frogs have an 84.6% chance to claim victory in this contest per the moneyline's implied probability. The Buffaloes have a 19.8% implied probability.
TCU has a record of 2-1-1 against the spread this season.
Colorado has covered three times in five matchups with a spread this year.

TCU vs. Colorado: Head-to-Head

TCU and Colorado have been evenly matched over their last two games, sharing the same 1-1 record.
The two teams have gone over the total on one occasion while sharing a split 1-1 record in their matchups against the spread.
Over their last two head-to-head contests, TCU has racked up 80 points, while Colorado has accumulated 58.

TCU vs. Colorado: 2025 Stats Comparison

	TCU	Colorado
Off. Points per Game (Rank)	37.3 (48)	25.8 (78)
Def. Points per Game (Rank)	21.5 (42)	22.8 (77)
Turnovers Allowed (Rank)	6 (74)	4 (25)
Turnovers Forced (Rank)	6 (51)	5 (71)

TCU 2025 Key Players

Name	Position	Stats
Josh Hoover	QB	1,242 YDS (66.7%) / 11 TD / 4 INT -8 RUSH YDS / 1 RUSH TD / -2 RUSH YPG
Eric McAlister	WR	13 REC / 320 YDS / 3 TD / 80 YPG
Jordan Dwyer	WR	20 REC / 299 YDS / 2 TD / 74.8 YPG
Jeremy Payne	RB	130 YDS / 1 TD / 32.5 YPG / 4.5 YPC 11 REC / 78 REC YDS / 1 REC TD / 19.5 REC YPG
Kaleb Elarms-Orr	LB	24 TKL / 4 TFL / 3 SACK
Jamel Johnson	DB	21 TKL / 0 TFL / 2 INT / 2 PD
Devean Deal	DL	13 TKL / 0 TFL / 1 SACK
Kylin Jackson	DB	11 TKL / 3 TFL / 1.5 SACK

Colorado 2025 Key Players

Name	Position	Stats
Kaidon Salter	QB	684 YDS (67%) / 5 TD / 1 INT 203 RUSH YDS / 4 RUSH TD / 50.8 RUSH YPG
Joseph Williams	WR	14 REC / 220 YDS / 2 TD / 44 YPG
Sincere Brown	WR	8 REC / 211 YDS / 2 TD / 42.2 YPG
Dekalon Taylor	RB	83 YDS / 0 TD / 20.8 YPG / 4.4 YPC 10 REC / 106 REC YDS / 2 REC TD / 35.3 REC YPG
Martavius French	LB	13 TKL / 2 TFL / 1 SACK
Keaten Wade	DL	12 TKL / 3 TFL / 1.5 SACK
Tawfiq Byard	DB	18 TKL / 1 TFL / 0.5 SACK
Jeremiah Brown	LB	13 TKL / 1 TFL