Southern Miss vs. Louisiana Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 3:04 p.m. ET

Data Skrive

Sun Belt foes meet when the Southern Miss Golden Eagles (4-2) visit the Louisiana Ragin' Cajuns (2-4) on Saturday, October 18, 2025 at Cajun Field at Our Lady of Lourdes Stadium. Southern Miss is favored by 3.5 points. The point total is 54.5 for the game.

The Golden Eagles' last contest was versus the Georgia Southern Eagles, and they won by a score of 38-35. Facing the James Madison Dukes in their last contest, the Ragin' Cajuns lost 24-14.

Keep up with college football all season on FOX Sports.

Southern Miss vs. Louisiana Game Information & Odds

When: Saturday, October 18, 2025 at 5 p.m. ET
Location: Cajun Field at Our Lady of Lourdes Stadium in Lafayette, Louisiana
TV: ESPN+
Live Box Score on FOX Sports

Southern Miss vs Louisiana Betting Information updated as of October 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Southern Miss	-3.5 (-110)	-172	+143	54.5	-111	-109

Southern Miss vs. Louisiana Prediction

Pick ATS: Southern Miss (-3.5)
Pick OU: Over (54.5)
Prediction: Southern Miss 35, Louisiana 24

Predictions are made by the Data Skrive betting model.

Learn more about the Southern Miss Golden Eagles vs. the Louisiana Ragin' Cajuns game on FOX Sports!

Southern Miss vs. Louisiana Betting Insights

Per the spread and over/under, the implied score for the game is Golden Eagles 29, Ragin' Cajuns 26.
The Golden Eagles have a 63.2% chance to win this meeting based on the moneyline's implied probability. The Ragin' Cajuns have a 41.2% implied probability.
Southern Miss has won three games against the spread this season, while failing to cover or pushing three times.
Louisiana has a record of 2-3-0 against the spread this year.

Southern Miss vs. Louisiana: Head-to-Head

Over their last three meetings, Southern Miss has collected two wins against Louisiana.
The Golden Eagles own a 3-0 record ATS in those games, while the two teams have gone over the total on two occasions.
Over their last three head-to-head contests, Southern Miss has scored 86 points, while Louisiana has compiled 78.

Southern Miss vs. Louisiana: 2025 Stats Comparison

	Southern Miss	Louisiana
Off. Points per Game (Rank)	32.2 (57)	25.8 (93)
Def. Points per Game (Rank)	27.7 (85)	30.8 (110)
Turnovers Allowed (Rank)	5 (19)	7 (56)
Turnovers Forced (Rank)	13 (5)	8 (55)

Southern Miss 2025 Key Players

Name	Position	Stats
Braylon Braxton	QB	1,473 YDS (65.3%) / 13 TD / 3 INT 186 RUSH YDS / 1 RUSH TD / 31 RUSH YPG
Jeffery Pittman	RB	346 YDS / 6 TD / 69.2 YPG / 4.7 YPC 12 REC / 64 REC YDS / 0 REC TD / 16 REC YPG
Carl Chester	WR	16 REC / 300 YDS / 3 TD / 50 YPG
Micah Davis	WR	15 REC / 151 YDS / 3 TD / 25.2 YPG
Michael Montgomery	LB	33 TKL / 1 TFL / 1.5 SACK / 2 INT
Chris Jones	LB	36 TKL / 3 TFL / 2.5 SACK
J'Mond Tapp	DL	24 TKL / 6 TFL / 4 SACK
Ian Foster	DB	20 TKL / 2 TFL / 1 SACK / 2 INT

Louisiana 2025 Key Players

Name	Position	Stats
Zylan Perry	RB	411 YDS / 5 TD / 82.2 YPG / 7 YPC
Lunch Winfield	QB	372 YDS (46.9%) / 4 TD / 1 INT 171 RUSH YDS / 3 RUSH TD / 34.2 RUSH YPG
Elijah Davis	RB	335 YDS / 3 TD / 55.8 YPG / 4.8 YPC
Dale Martin	WR	4 REC / 107 YDS / 2 TD / 53.5 YPG
Jaden Dugger	LB	43 TKL / 3 TFL / 1 SACK
Terrence Williams	LB	27 TKL / 2 TFL / 1 SACK
Courtline Flowers	DB	20 TKL / 3 TFL / 1 SACK / 1 INT
Jake St. Andre	LB	29 TKL / 1 TFL / 0.5 SACK