South Carolina vs. Clemson Prediction, Odds, Picks - November 29, 2025

Updated Nov. 29, 2025 9:04 a.m. ET

FOX Sports

The South Carolina Gamecocks (4-7) and the Clemson Tigers (6-5) square off in the 2025 edition of the Palmetto Bowl on Saturday, Nov. 29. The Gamecocks are just 2.5-point favorites. The contest's over/under is 46.5.

In their most recent action, the Gamecocks won against the Coastal Carolina Chanticleers, 51-7. In their last game, the Tigers won against the Furman Paladins, 45-10.

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South Carolina vs. Clemson Game Information & Odds

When: Saturday, November 29, 2025 at 12 p.m. ET
Location: Williams-Brice Stadium in Columbia, South Carolina
TV: SEC Network
Live Box Score on FOX Sports

South Carolina vs Clemson Betting Information updated as of November 29, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
South Carolina	-2.5 (-115)	-141	+119	46.5	-110	-110

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South Carolina vs. Clemson Prediction

Pick ATS: South Carolina (-2.5)
Pick OU: Over (46.5)
Prediction: South Carolina 26, Clemson 21

Predictions are made by the Data Skrive betting model.

Learn more about the South Carolina Gamecocks vs. the Clemson Tigers game on FOX Sports!

South Carolina vs. Clemson Betting Insights

Per the spread and over/under, the implied score for the tilt is Gamecocks 24, Tigers 22.
The Gamecocks have a 58.5% chance to collect the win in this contest based on the moneyline's implied probability. The Tigers hold a 45.7% implied probability.
South Carolina has put together a 6-5-0 record against the spread this season.
Clemson has covered four times in 11 games with a spread this season.

South Carolina vs. Clemson: Head-to-Head

South Carolina and Clemson have been matched up evenly over their last four matchups, sharing the same 2-2 record.
The Gamecocks and the Tigers have matched up evenly over their last four games, sporting an even 2-2 record against the spread. In those four games, the two teams have gone over the point total on one occasion.
South Carolina has been outpaced by 35 points in its last four tilts versus Clemson.

South Carolina vs. Clemson: 2025 Stats Comparison

	South Carolina	Clemson
Off. Points per Game (Rank)	23.5 (101)	28.7 (64)
Def. Points per Game (Rank)	21.5 (37)	21 (33)
Turnovers Allowed (Rank)	13 (51)	14 (67)
Turnovers Forced (Rank)	20 (13)	13 (79)

South Carolina 2025 Key Players

Name	Position	Stats
LaNorris Sellers	QB	2,056 YDS (61.8%) / 11 TD / 6 INT 268 RUSH YDS / 5 RUSH TD / 24.4 RUSH YPG
Nyck Harbor	WR	24 REC / 503 YDS / 5 TD / 50.3 YPG
Rahsul Faison	RB	433 YDS / 3 TD / 39.4 YPG / 4.8 YPC 18 REC / 106 REC YDS / 0 REC TD / 11.8 REC YPG
Vandrevius Jacobs	WR	25 REC / 407 YDS / 3 TD / 45.2 YPG
Bryan Thomas Jr.	DL	33 TKL / 7 TFL / 7 SACK
Dylan Stewart	DL	30 TKL / 10 TFL / 5 SACK
Fred Johnson	LB	49 TKL / 4 TFL / 1 SACK / 1 INT
Justin Okoronkwo	LB	59 TKL / 4 TFL / 1 INT / 1 PD

Clemson 2025 Key Players

Name	Position	Stats
Cade Klubnik	QB	2,482 YDS (67.2%) / 16 TD / 5 INT 95 RUSH YDS / 3 RUSH TD / 9.5 RUSH YPG
Adam Randall	RB	677 YDS / 8 TD / 61.5 YPG / 5.1 YPC 30 REC / 247 REC YDS / 3 REC TD / 24.7 REC YPG
Antonio Williams	WR	48 REC / 538 YDS / 4 TD / 59.8 YPG
Bryant Wesco Jr.	WR	31 REC / 537 YDS / 6 TD / 76.7 YPG
Sammy Brown	LB	75 TKL / 9 TFL / 5 SACK / 1 INT
Avieon Terrell	DB	44 TKL / 3 TFL / 3 SACK
Wade Woodaz	LB	61 TKL / 6 TFL / 0.5 SACK
Will Heldt	DL	35 TKL / 9 TFL / 5 SACK