Pittsburgh vs. West Virginia Prediction, Odds, Picks - September 13, 2025

Updated Sep. 13, 2025 3:04 p.m. ET

FOX Sports

The Pittsburgh Panthers (2-0) and the West Virginia Mountaineers (1-1) take the field for the Backyard Brawl on Saturday, September 13, 2025 at Mountaineer Field at Milan Puskar Stadium. The Panthers are 7-point favorites. The point total is set at 55.5 for the contest.

The Panthers beat the Central Michigan Chippewas, 45-17, in their last contest. The Mountaineers' most recent contest was against the Ohio Bobcats, and they lost by a score of 17-10.

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Pittsburgh vs. West Virginia Game Information & Odds

When: Saturday, September 13, 2025 at 3:30 p.m. ET
Location: Mountaineer Field at Milan Puskar Stadium in Morgantown, West Virginia
TV: ESPN
Live Box Score on FOX Sports

Pittsburgh vs West Virginia Betting Information updated as of September 13, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Pittsburgh	-7 (-110)	-279	+225	55.5	-110	-110

Pittsburgh vs. West Virginia Prediction

Pick ATS: West Virginia (+7)
Pick OU: Under (55.5)
Prediction: Pittsburgh 24, West Virginia 21

Predictions are made by the Data Skrive betting model.

Learn more about the Pittsburgh Panthers vs. the West Virginia Mountaineers game on FOX Sports!

Pittsburgh vs. West Virginia Betting Insights

Based on the spread and over/under, the implied score for the game is Panthers 31, Mountaineers 24.
The Panthers have a 73.6% chance to claim victory in this game based on the moneyline's implied probability. The Mountaineers have a 30.8% implied probability.
Pittsburgh has a record of 2-0-0 against the spread this season.
West Virginia has a record of 1-1-0 against the spread this season.

Pittsburgh vs. West Virginia: Head-to-Head

Pittsburgh holds a 2-1 record against West Virginia in their last three matchups.
In those matchups against Pittsburgh, the Mountaineers have covered two times while outscoring the total on two occasions.
West Virginia has scored 82 points in its last three contests against Pittsburgh, matching the Panthers' offensive output (82 points) in those games.

Pittsburgh vs. West Virginia: 2025 Stats Comparison

	Pittsburgh	West Virginia
Off. Points per Game (Rank)	53 (13)	27.5 (77)
Def. Points per Game (Rank)	13 (37)	10 (22)
Turnovers Allowed (Rank)	2 (54)	5 (122)
Turnovers Forced (Rank)	1 (96)	5 (7)

Pittsburgh 2025 Key Players

Name	Position	Stats
Eli Holstein	QB	519 YDS (70.6%) / 8 TD / 2 INT 77 RUSH YDS / 0 RUSH TD / 38.5 RUSH YPG
Desmond Reid	RB	112 YDS / 1 TD / 56 YPG / 6.2 YPC 6 REC / 71 REC YDS / 0 REC TD / 35.5 REC YPG
Raphael Williams	WR	7 REC / 166 YDS / 2 TD / 83 YPG
Cataurus Hicks	WR	5 REC / 74 YDS / 2 TD / 37 YPG
Kyle Louis	LB	11 TKL / 4 TFL / 2 SACK
Zach Crothers	DL	9 TKL / 1 TFL / 1.5 SACK
Joseph Zelinsky	DL	4 TKL / 1 TFL / 1.5 SACK
Rasheem Biles	LB	14 TKL / 1 TFL

West Virginia 2025 Key Players

Name	Position	Stats
Jahiem White	RB	133 YDS / 3 TD / 66.5 YPG / 5.5 YPC
Nicco Marchiol	QB	402 YDS (69.6%) / 1 TD / 1 INT 65 RUSH YDS / 1 RUSH TD / 32.5 RUSH YPG
Cam Vaughn	WR	9 REC / 169 YDS / 1 TD / 84.5 YPG
Scotty Fox Jr.	QB	8 YDS (100%) / 0 TD / 0 INT 63 RUSH YDS / 1 RUSH TD / 63 RUSH YPG
Chase Wilson	LB	13 TKL / 4 TFL / 3 SACK / 1 INT
Hammond Russell IV	DL	7 TKL / 2 TFL / 2 SACK
Fred Perry	DB	14 TKL / 1 TFL / 1 SACK
Darrian Lewis	DB	14 TKL / 0 TFL / 1 INT / 1 PD