Penn State vs. Northwestern Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 3:04 p.m. ET

Data Skrive

The Penn State Nittany Lions (3-2) will test their 20th-ranked scoring offense against the Northwestern Wildcats (3-2), who have the No. 95 scoring defense in college football, on Saturday, October 11, 2025. The Nittany Lions are heavily favored by 21.5 points in the outing. A 47.5-point over/under is set for the game.

Against the UCLA Bruins in their last contest, the Nittany Lions lost 42-37. The Wildcats' most recent game was against the Louisiana-Monroe Warhawks, and they won by a score of 42-7.

Keep up with college football all season on FOX Sports.

Penn State vs. Northwestern Game Information & Odds

When: Saturday, October 11, 2025 at 3:30 p.m. ET
Location: West Shore Home Field at Beaver Stadium in University Park, Pennsylvania
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Penn State vs Northwestern Betting Information updated as of October 11, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Penn State	-21.5 (-108)	-1538	+910	47.5	-110	-110

Penn State vs. Northwestern Prediction

Pick ATS: Northwestern (+21.5)
Pick OU: Under (47.5)
Prediction: Penn State 24, Northwestern 23

Predictions are made by the Data Skrive betting model.

Learn more about the Penn State Nittany Lions vs. the Northwestern Wildcats game on FOX Sports!

Penn State vs. Northwestern Betting Insights

Based on the spread and over/under, the implied score for the tilt is Nittany Lions 34, Wildcats 13.
The Nittany Lions have a 93.9% chance to collect the win in this meeting per the moneyline's implied probability. The Wildcats have a 9.9% implied probability.
Penn State has put together a 0-5-0 record against the spread this season.
Northwestern is 3-2-0 ATS this year.

Penn State vs. Northwestern: Head-to-Head

Penn State holds a 2-0 record against Northwestern in their last two matchups.
The two teams have gone over the total on one occasion while sharing an even 1-1 record in their games against the spread.
In their last two head-to-head matchups, Penn State has compiled 58 points against Northwestern, while allowing only 20 points.

Penn State vs. Northwestern: 2025 Stats Comparison

	Penn State	Northwestern
Off. Points per Game (Rank)	38.6 (30)	23.6 (103)
Def. Points per Game (Rank)	17.8 (27)	17 (23)
Turnovers Allowed (Rank)	3 (9)	8 (93)
Turnovers Forced (Rank)	7 (55)	2 (129)

Penn State 2025 Key Players

Name	Position	Stats
Drew Allar	QB	963 YDS (64.7%) / 8 TD / 2 INT 147 RUSH YDS / 0 RUSH TD / 29.4 RUSH YPG
Kaytron Allen	RB	377 YDS / 6 TD / 75.4 YPG / 7 YPC
Nicholas Singleton	RB	239 YDS / 5 TD / 47.8 YPG / 3.8 YPC 10 REC / 89 REC YDS / 0 REC TD / 17.8 REC YPG
Kyron Ware-Hudson	WR	18 REC / 208 YDS / 2 TD / 41.6 YPG
Amare Campbell	LB	46 TKL / 5 TFL / 2 SACK
Dani Dennis-Sutton	DL	19 TKL / 4 TFL / 2 SACK
Zakee Wheatley	DB	30 TKL / 1 TFL
Tony Rojas	LB	24 TKL / 4 TFL / 2 SACK

Northwestern 2025 Key Players

Name	Position	Stats
Caleb Komolafe	RB	344 YDS / 4 TD / 68.8 YPG / 4.5 YPC
Preston Stone	QB	918 YDS (61.5%) / 7 TD / 6 INT
Griffin Wilde	WR	25 REC / 375 YDS / 2 TD / 75 YPG
Joseph Himon II	RB	208 YDS / 0 TD / 41.6 YPG / 5.5 YPC 10 REC / 59 REC YDS / 0 REC TD / 11.8 REC YPG
Mac Uihlein	LB	34 TKL / 2 TFL / 2 INT / 2 PD
Robert Fitzgerald	DB	41 TKL / 2 TFL
Aidan Hubbard	DL	13 TKL / 3 TFL / 2.5 SACK
Braydon Brus	LB	20 TKL / 1 TFL / 0.5 SACK