Ohio State vs. UCLA Prediction, Odds, Picks - November 15, 2025

Updated Nov. 15, 2025 3:04 p.m. ET

Data Skrive

The No. 1 Ohio State Buckeyes (9-0) host the UCLA Bruins (3-6) on Saturday, November 15, 2025 in a matchup between Big Ten foes at Ohio Stadium. UCLA is a 34.5-point underdog. The total is 47 points for this game.

Last time around, the Buckeyes defeated the Purdue Boilermakers, with 34-10 being the final score. The Bruins lost to the Nebraska Cornhuskers, 28-21, in their last game.

Keep up with college football all season on FOX Sports.

Ohio State vs. UCLA Game Information & Odds

When: Saturday, November 15, 2025 at 7:30 p.m. ET
Location: Ohio Stadium in Columbus, Ohio
TV: NBC
Live Box Score on FOX Sports

Ohio State vs UCLA Betting Information updated as of November 15, 2025, 1:46 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ohio State	-34.5 (-107)	-10000	+2333	47	-110	-111

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Ohio State vs. UCLA Prediction

Pick ATS: UCLA (+34.5)
Pick OU: Under (47)
Prediction: Ohio State 40, UCLA 6

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the UCLA Bruins game on FOX Sports!

Ohio State vs. UCLA Betting Insights

Based on the spread and over/under, the implied score for the game is Buckeyes 41, Bruins 6.
The Buckeyes have a 99.0% chance to claim victory in this contest based on the moneyline's implied probability. The Bruins have a 4.1% implied probability.
Ohio State has won seven games against the spread this season, while failing to cover twice.
UCLA is 3-6-0 ATS this year.

Ohio State vs. UCLA: 2025 Stats Comparison

	Ohio State	UCLA
Off. Points per Game (Rank)	36.3 (19)	20.4 (119)
Def. Points per Game (Rank)	7.2 (1)	30.7 (103)
Turnovers Allowed (Rank)	6 (3)	10 (41)
Turnovers Forced (Rank)	10 (88)	8 (109)

Ohio State 2025 Key Players

Name	Position	Stats
Julian Sayin	QB	2,491 YDS (80.9%) / 24 TD / 4 INT
Jeremiah Smith	WR	65 REC / 862 YDS / 10 TD / 95.8 YPG
Carnell Tate	WR	39 REC / 711 YDS / 7 TD / 88.9 YPG
Bo Jackson	RB	613 YDS / 2 TD / 76.6 YPG / 6.5 YPC 12 REC / 124 REC YDS / 1 REC TD / 20.7 REC YPG
Arvell Reese	LB	55 TKL / 8 TFL / 6.5 SACK
Caden Curry	DL	36 TKL / 10 TFL / 7 SACK
Kayden McDonald	DL	37 TKL / 5 TFL / 3 SACK
Sonny Styles	LB	48 TKL / 2 TFL / 1 INT / 1 PD

UCLA 2025 Key Players

Name	Position	Stats
Nico Iamaleava	QB	1,659 YDS (63.7%) / 12 TD / 7 INT 474 RUSH YDS / 4 RUSH TD / 52.7 RUSH YPG
Jalen Berger	RB	268 YDS / 2 TD / 29.8 YPG / 4.2 YPC 8 REC / 64 REC YDS / 2 REC TD / 12.8 REC YPG
Anthony Woods	RB	232 YDS / 0 TD / 29 YPG / 4.8 YPC 17 REC / 166 REC YDS / 2 REC TD / 23.7 REC YPG
Kwazi Gilmer	WR	33 REC / 395 YDS / 2 TD / 43.9 YPG
JonJon Vaughns	LB	78 TKL / 3 TFL
Key Lawrence	DB	49 TKL / 3 TFL / 1 INT / 1 PD
Isaiah Chisom	LB	62 TKL / 1 TFL
Cole Martin	DB	45 TKL / 3 TFL