Nebraska vs. Michigan State Prediction, Odds, Picks - October 4, 2025

Updated Oct. 4, 2025 3:05 p.m. ET

Data Skrive

The Nebraska Cornhuskers (3-1) are 12.5-point favorites when they host the Michigan State Spartans (3-1) in a Big Ten matchup on Saturday, October 4, 2025 at Memorial Stadium (Lincoln, NE). The game has a 48.5-point over/under.

In their last action, the Cornhuskers lost versus the Michigan Wolverines, 30-27. The Spartans' last contest was against the USC Trojans, and they lost by a score of 45-31.

Keep up with college football all season on FOX Sports.

Nebraska vs. Michigan State Game Information & Odds

When: Saturday, October 4, 2025 at 4 p.m. ET
Location: Memorial Stadium (Lincoln, NE) in Lincoln, Nebraska
TV: Fox Sports 1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Nebraska vs Michigan State Betting Information updated as of October 4, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Nebraska	-12.5 (-112)	-505	+378	48.5	-110	-111

Nebraska vs. Michigan State Prediction

Pick ATS: Nebraska (-12.5)
Pick OU: Over (48.5)
Prediction: Nebraska 37, Michigan State 21

Predictions are made by the Data Skrive betting model.

Learn more about the Nebraska Cornhuskers vs. the Michigan State Spartans game on FOX Sports!

Nebraska vs. Michigan State Betting Insights

Per the spread and over/under, the implied score for the tilt is Cornhuskers 30, Spartans 18.
The Cornhuskers have an 83.5% chance to win this contest based on the moneyline's implied probability. The Spartans hold a 20.9% implied probability.
Nebraska has a record of 2-2-0 against the spread this season.
Michigan State has covered once in four matchups with a spread this season.

Nebraska vs. Michigan State: Head-to-Head

In their past two head-to-head contests, Michigan State has defeated Nebraska two times.
In their most recent two meetings, each team has covered one time with those contests outscoring the total on one occasion.
In their last two head-to-head matchups, Michigan State has scored 43 points versus Nebraska, while allowing only 37 points.

Nebraska vs. Michigan State: 2025 Stats Comparison

	Nebraska	Michigan State
Off. Points per Game (Rank)	43.5 (27)	34.3 (68)
Def. Points per Game (Rank)	13.5 (10)	28.8 (80)
Turnovers Allowed (Rank)	2 (8)	4 (25)
Turnovers Forced (Rank)	6 (51)	4 (93)

Nebraska 2025 Key Players

Name	Position	Stats
Dylan Raiola	QB	1,139 YDS (75.6%) / 11 TD / 1 INT
Emmett Johnson	RB	391 YDS / 4 TD / 97.8 YPG / 5.5 YPC 16 REC / 73 REC YDS / 1 REC TD / 18.3 REC YPG
Jacory Barney Jr.	WR	21 REC / 301 YDS / 3 TD / 75.3 YPG
Dane Key	WR	16 REC / 226 YDS / 3 TD / 56.5 YPG
Dasan McCullough	LB	7 TKL / 3 TFL / 2 SACK
Javin Wright	LB	16 TKL / 2 TFL
Williams Nwaneri	DL	9 TKL / 0 TFL
Vincent Shavers Jr.	LB	10 TKL / 1 TFL

Michigan State 2025 Key Players

Name	Position	Stats
Aidan Chiles	QB	868 YDS (68.6%) / 9 TD / 1 INT 154 RUSH YDS / 2 RUSH TD / 38.5 RUSH YPG
Nick Marsh	WR	18 REC / 222 YDS / 3 TD / 55.5 YPG
Makhi Frazier	RB	267 YDS / 2 TD / 66.8 YPG / 4.7 YPC
Omari Kelly	WR	21 REC / 317 YDS / 1 TD / 79.3 YPG
Jordan Hall	LB	28 TKL / 3 TFL / 2 SACK
Wayne Matthews III	LB	25 TKL / 0 TFL / 1 INT / 1 PD
Malik Spencer	DB	18 TKL / 1 TFL / 1 SACK
Armorion Smith	DB	12 TKL / 0 TFL / 1 INT / 1 PD