LSU vs. Western Kentucky Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

Data Skrive

The LSU Tigers (6-4) are big 23.5-point favorites on Saturday, November 22, 2025 against the Western Kentucky Hilltoppers (8-2). A 51.5-point over/under is set for the contest.

The Tigers beat the Arkansas Razorbacks, 23-22, in their last game. The Hilltoppers' most recent game was versus the Middle Tennessee Blue Raiders, and they won by a score of 42-26.

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LSU vs. Western Kentucky Game Information & Odds

When: Saturday, November 22, 2025 at 7:45 p.m. ET
Location: Tiger Stadium in Baton Rouge, Louisiana
TV: SEC Network
Live Box Score on FOX Sports

LSU vs Western Kentucky Betting Information updated as of November 22, 2025, 12:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
LSU	-23.5 (-112)	-2703	+1220	51.5	-112	-108

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LSU vs. Western Kentucky Prediction

Pick ATS: Western Kentucky (+23.5)
Pick OU: Under (51.5)
Prediction: LSU 33, Western Kentucky 14

Predictions are made by the Data Skrive betting model.

Learn more about the LSU Tigers vs. the Western Kentucky Hilltoppers game on FOX Sports!

LSU vs. Western Kentucky Betting Insights

Per the spread and over/under, the implied score for the tilt is Tigers 38, Hilltoppers 14.
The Tigers have a 96.4% chance to collect the win in this contest based on the moneyline's implied probability. The Hilltoppers have a 7.6% implied probability.
LSU has put together a 3-7-0 record against the spread this season.
Western Kentucky is 8-2-0 ATS this season.

LSU vs. Western Kentucky: 2025 Stats Comparison

	LSU	Western Kentucky
Off. Points per Game (Rank)	23.6 (102)	31.3 (48)
Def. Points per Game (Rank)	19.3 (19)	23.1 (49)
Turnovers Allowed (Rank)	10 (25)	14 (79)
Turnovers Forced (Rank)	16 (32)	10 (100)

LSU 2025 Key Players

Name	Position	Stats
Garrett Nussmeier	QB	1,925 YDS (67.4%) / 12 TD / 5 INT -57 RUSH YDS / 1 RUSH TD / -6.3 RUSH YPG
Caden Durham	RB	447 YDS / 3 TD / 49.7 YPG / 4.8 YPC 15 REC / 90 REC YDS / 0 REC TD / 11.3 REC YPG
Zavion Thomas	WR	31 REC / 396 YDS / 3 TD / 39.6 YPG
Barion Brown	WR	44 REC / 449 YDS / 1 TD / 44.9 YPG
Harold Perkins	LB	37 TKL / 4 TFL / 4 SACK / 2 INT
West Weeks	LB	53 TKL / 5 TFL / 1.5 SACK
Adari Haulcy	DB	49 TKL / 0 TFL / 2 INT / 2 PD
Tamarcus Cooley	DB	40 TKL / 0 TFL / 2 INT / 2 PD

Western Kentucky 2025 Key Players

Name	Position	Stats
Maverick McIvor	QB	1,863 YDS (67.3%) / 12 TD / 5 INT 28 RUSH YDS / 1 RUSH TD / 4 RUSH YPG
Matthew Henry	WR	42 REC / 703 YDS / 6 TD / 70.3 YPG
La'Vell Wright	RB	327 YDS / 8 TD / 32.7 YPG / 5.4 YPC 9 REC / 81 REC YDS / 1 REC TD / 9 REC YPG
Rodney Tisdale Jr.	QB	1,059 YDS (72.1%) / 9 TD / 3 INT 123 RUSH YDS / 1 RUSH TD / 24.6 RUSH YPG
Jaylen Wester	LB	49 TKL / 1 TFL / 0.5 SACK
Jaylen Lewis	DB	29 TKL / 2 TFL / 2 INT / 2 PD
Dave Herard	DB	33 TKL / 1 TFL
Anthony Brackenridge	LB	31 TKL / 2 TFL