Louisville vs. Indiana Prediction, Odds, Picks - September 16

Updated Sep. 16, 2023 9:05 a.m. ET

FOX Sports

Lucas Oil Stadium in Indianapolis, Indiana is the setting for the Louisville Cardinals' (2-0) matchup against the Indiana Hoosiers (1-1) on September 16, 2023, starting at 12:00 PM ET, airing on BTN. The Cardinals are a 10-point favorite in the matchup. The over/under for the outing is set at 50.

In their most recent action, the Cardinals won against the Murray State Racers, 56-0. Last time around, the Hoosiers defeated the Indiana State Sycamores, with 41-7 being the final score.

Louisville vs. Indiana Game Information & Odds

When: Saturday, September 16, 2023 at 12:00 PM ET
Location: Lucas Oil Stadium in Indianapolis, Indiana
TV: BTN
Live boxscore on FOX Sports

Louisville vs Indiana Betting Information updated as of September 16, 2023, 8:45 AM ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisville	-10 (-110)	-362	+283	50	-110	-110

Louisville vs. Indiana Prediction

Pick ATS: Indiana (+10)
Pick OU: Under (50)
Prediction: Louisville 28, Indiana 21

Learn more about the Louisville Cardinals vs. the Indiana Hoosiers game on FOX Sports!

Louisville vs. Indiana Betting Insights

Per the spread and over/under, the implied score for the game is Cardinals 30, Hoosiers 20.
The Cardinals have a 78.4% chance to win this meeting per the moneyline's implied probability. The Hoosiers have a 26.1% implied probability.
Louisville has won one game against the spread this season.
Indiana has put together a perfect 1-0-0 record against the spread this season.

Louisville vs. Indiana: 2023 Stats Comparison

	Louisville	Indiana
Off. Points per Game (Rank)	47.5 (18)	22.0 (106)
Def. Points per Game (Rank)	17.0 (39)	15.0 (30)
Turnovers Allowed (Rank)	3 (71)	1 (9)
Turnovers Forced (Rank)	5 (13)	2 (72)

Louisville 2023 Key Players

Name	Position	Stats
Jawhar Jordan	RB	231 YDS / 3 TD / 115.5 YPG / 16.5 YPC 3 REC / 49 REC YDS / 0 REC TD / 24.5 REC YPG
Jamari Thrash	WR	10 REC / 170 YDS / 3 TD / 85.0 YPG
Jack Plummer	QB	494 YDS (64.2%) / 4 TD / 3 INT 56 RUSH YDS / 0 RUSH TD / 28.0 RUSH YPG
Isaac Guerendo	RB	90 YDS / 1 TD / 45.0 YPG / 5.3 YPC 5 REC / 60 REC YDS / 0 REC TD / 30.0 REC YPG
Devin Neal	DB	9 TKL / 0.0 TFL / 1 INT / 1 PD
TJ Quinn	LB	11 TKL / 0.0 TFL
Dezmond Tell	DL	5 TKL / 0.0 TFL / 1.0 SACK
Ramon Puryear	DL	4 TKL / 1.0 TFL / 1 INT / 1 PD

Indiana 2023 Key Players

Name	Position	Stats
Jaylin Lucas	RB	112 YDS / 2 TD / 56.0 YPG / 5.3 YPC 5 REC / 40 REC YDS / 0 REC TD / 20.0 REC YPG
Tayven Jackson	QB	260 YDS (73.1%) / 0 TD / 0 INT 20 RUSH YDS / 1 RUSH TD / 10.0 RUSH YPG
Josh Henderson	RB	65 YDS / 1 TD / 32.5 YPG / 4.3 YPC 4 REC / 58 REC YDS / 0 REC TD / 29.0 REC YPG
Omar Cooper Jr.	WR	7 REC / 101 YDS / 0 TD / 50.5 YPG
Aaron Casey	LB	19 TKL / 1.0 TFL
Phillip Dunnam	DB	14 TKL / 0.0 TFL / 1 INT / 1 PD
Andre Carter	DL	7 TKL / 4.0 TFL / 1.0 SACK
Lanell Carr	OLB	7 TKL / 2.0 TFL / 1.0 SACK