Iowa vs. Nebraska Prediction, Odds, Picks - November 28, 2025

Updated Nov. 28, 2025 9:05 a.m. ET

Data Skrive

The Iowa Hawkeyes (7-4) are 6-point favorites on the road at Memorial Stadium (Lincoln, NE) against the Nebraska Cornhuskers (7-4) on Friday, November 28, 2025. Both squads have stout pass defenses, with the Hawkeyes 11th against the pass in the nation, and the Cornhuskers second defending the passing attack. The contest has a 39.5-point over/under.

The Hawkeyes won against the Michigan State Spartans in their most recent game, 20-17. Against the Penn State Nittany Lions in their last contest, the Cornhuskers lost 37-10.

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Iowa vs. Nebraska Game Information & Odds

When: Friday, November 28, 2025 at 12 p.m. ET
Location: Memorial Stadium (Lincoln, NE) in Lincoln, Nebraska
TV: CBS
Live Box Score on FOX Sports

Iowa vs Nebraska Betting Information updated as of November 28, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Iowa	-6 (-110)	-233	+191	39.5	-110	-110

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Iowa vs. Nebraska Prediction

Pick ATS: Iowa (-6)
Pick OU: Over (39.5)
Prediction: Iowa 27, Nebraska 20

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa Hawkeyes vs. the Nebraska Cornhuskers game on FOX Sports!

Iowa vs. Nebraska Betting Insights

Based on the spread and over/under, the implied score for the game is Hawkeyes 23, Cornhuskers 17.
The Hawkeyes have a 70.0% chance to claim victory in this game per the moneyline's implied probability. The Cornhuskers hold a 34.4% implied probability.
Iowa has covered seven times in 11 games with a spread this season.
Nebraska has covered four times in 11 chances against the spread this season.

Iowa vs. Nebraska: Head-to-Head

In their last four head-to-head bouts, Iowa has beaten Nebraska three times.
The Hawkeyes own a 2-1-1 record ATS in those games, while the two teams have gone over the total on two occasions.
In their last four head-to-head matchups, Iowa has tallied 71 points against Nebraska, while surrendering only 65 points.

Iowa vs. Nebraska: 2025 Stats Comparison

	Iowa	Nebraska
Off. Points per Game (Rank)	27.9 (69)	30.5 (47)
Def. Points per Game (Rank)	15.1 (9)	21.5 (39)
Turnovers Allowed (Rank)	11 (25)	9 (9)
Turnovers Forced (Rank)	13 (74)	12 (87)

Iowa 2025 Key Players

Name	Position	Stats
Mark Gronowski	QB	1,363 YDS (62.9%) / 7 TD / 6 INT 427 RUSH YDS / 13 RUSH TD / 38.8 RUSH YPG
Kamari Moulton	RB	690 YDS / 2 TD / 76.7 YPG / 5 YPC 15 REC / 95 REC YDS / 0 REC TD / 13.6 REC YPG
Kaden Wetjen	WR	20 REC / 151 YDS / 1 TD / 15.1 YPG
Xavier Williams	RB	260 YDS / 3 TD / 28.9 YPG / 5.9 YPC
Karson Sharar	LB	72 TKL / 7 TFL / 2 SACK
Zach Lutmer	DB	61 TKL / 4 TFL / 1 SACK / 3 INT
Xavier Nwankpa	DB	64 TKL / 1 TFL / 1 INT / 1 PD
Koen Entringer	DB	66 TKL / 3 TFL

Nebraska 2025 Key Players

Name	Position	Stats
Emmett Johnson	RB	1,234 YDS / 11 TD / 112.2 YPG / 5.6 YPC 44 REC / 348 REC YDS / 3 REC TD / 31.6 REC YPG
Dylan Raiola	QB	2,002 YDS (72.4%) / 18 TD / 6 INT
Nyziah Hunter	WR	42 REC / 611 YDS / 5 TD / 55.5 YPG
Jacory Barney Jr.	WR	42 REC / 458 YDS / 4 TD / 41.6 YPG
Javin Wright	LB	71 TKL / 6 TFL / 1.5 SACK / 1 INT
DeShon Singleton	DB	61 TKL / 3 TFL / 1 SACK / 2 INT
Vincent Shavers Jr.	LB	46 TKL / 6 TFL / 1 SACK
Rex Guthrie	DB	48 TKL / 0 TFL