Iowa State vs. Oklahoma State Prediction, Odds, Picks - November 29, 2025

The Iowa State Cyclones (7-4) are 13.5-point favorites when they visit the Oklahoma State Cowboys (1-10) in a Big 12 matchup on Saturday, November 29, 2025 at Boone Pickens Stadium. The over/under is 46.5 for the outing.

Last time out, the Cyclones defeated the Kansas Jayhawks, with 38-14 being the final score. The Cowboys' most recent contest was versus the UCF Knights, and they lost by a score of 17-14.

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Iowa State vs. Oklahoma State Game Information & Odds

• When: Saturday, November 29, 2025 at 12 p.m. ET
• Location: Boone Pickens Stadium in Stillwater, Oklahoma
• TV: ESPNU
• Live Box Score on FOX Sports

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Iowa State vs. Oklahoma State Prediction

• Pick ATS: Iowa State (-13.5)
  
• Pick OU: Over (46.5)
  
• Prediction: Iowa State 37, Oklahoma State 12

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa State Cyclones vs. the Oklahoma State Cowboys game on FOX Sports!

Iowa State vs. Oklahoma State Betting Insights

• Based on the spread and over/under, the implied score for the tilt is Cyclones 30, Cowboys 16.
• The Cyclones have an 85.0% chance to win this meeting per the moneyline's implied probability. The Cowboys hold a 19.5% implied probability.
• Iowa State has compiled a 5-5-1 record against the spread this season.
• Oklahoma State has put together a 4-7-0 record against the spread this season.

Iowa State vs. Oklahoma State: Head-to-Head

• In their past three head-to-head matchups, Iowa State has taken down Oklahoma State two times.
• The last three times the Cowboys have matched up against the Cyclones, they have a 2-1 record against the spread. The scoring has gone over the point total on one occasion.
• Over their last three head-to-head matchups, Iowa State has racked up 72 points, while Oklahoma State has posted 68.

Iowa State vs. Oklahoma State: 2025 Stats Comparison

Iowa State 2025 Key Players

Oklahoma State 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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