Indiana vs. UCLA Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 9:04 a.m. ET

Data Skrive

The No. 2 Indiana Hoosiers (7-0), who have college football's 15th-ranked pass defense, meet the UCLA Bruins (3-4) and their 24th-ranked passing defense on Saturday, October 25, 2025. The Hoosiers are massive, 26.5-point favorites. A total of 53.5 points has been set for this matchup.

The Hoosiers' most recent game was versus the Michigan State Spartans, and they won by a score of 38-13. Last time out, the Bruins defeated the Maryland Terrapins, with 20-17 being the final score.

Keep up with college football all season on FOX Sports.

Indiana vs. UCLA Game Information & Odds

When: Saturday, October 25, 2025 at 12 p.m. ET
Location: Memorial Stadium (Bloomington, IN) in Bloomington, Indiana
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Indiana vs UCLA Betting Information updated as of October 25, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Indiana	-26.5 (-111)	-4167	+1460	53.5	-111	-108

Indiana vs. UCLA Prediction

Pick ATS: Indiana (-26.5)
Pick OU: Under (53.5)
Prediction: Indiana 42, UCLA 9

Predictions are made by the Data Skrive betting model.

Learn more about the Indiana Hoosiers vs. the UCLA Bruins game on FOX Sports!

Indiana vs. UCLA Betting Insights

Based on the spread and over/under, the implied score for the tilt is Hoosiers 40, Bruins 14.
The Hoosiers have a 97.7% chance to collect the win in this game per the moneyline's implied probability. The Bruins have a 6.4% implied probability.
Indiana is 4-3-0 ATS this season.
UCLA has covered three times in seven matchups with a spread this season.

Indiana vs. UCLA: 2025 Stats Comparison

	Indiana	UCLA
Off. Points per Game (Rank)	43.9 (4)	22.4 (105)
Def. Points per Game (Rank)	11.6 (5)	27.4 (91)
Turnovers Allowed (Rank)	3 (4)	7 (37)
Turnovers Forced (Rank)	10 (40)	6 (99)

Indiana 2025 Key Players

Name	Position	Stats
Fernando Mendoza	QB	1,755 YDS (73.5%) / 21 TD / 2 INT 151 RUSH YDS / 2 RUSH TD / 21.6 RUSH YPG
Omar Cooper Jr.	WR	38 REC / 605 YDS / 7 TD / 86.4 YPG
Elijah Sarratt	WR	42 REC / 579 YDS / 9 TD / 82.7 YPG
Roman Hemby	RB	432 YDS / 2 TD / 61.7 YPG / 4.8 YPC 9 REC / 120 REC YDS / 0 REC TD / 20 REC YPG
Isaiah Jones	LB	31 TKL / 9 TFL / 4.5 SACK / 1 INT
Louis Moore	DB	42 TKL / 2 TFL / 3 INT / 3 PD
Aiden Fisher	LB	40 TKL / 5 TFL / 2.5 SACK
Rolijah Hardy	LB	31 TKL / 7 TFL / 4 SACK

UCLA 2025 Key Players

Name	Position	Stats
Nico Iamaleava	QB	1,355 YDS (65.2%) / 10 TD / 5 INT 360 RUSH YDS / 4 RUSH TD / 51.4 RUSH YPG
Kwazi Gilmer	WR	30 REC / 369 YDS / 2 TD / 52.7 YPG
Jalen Berger	RB	232 YDS / 1 TD / 33.1 YPG / 4.3 YPC 6 REC / 45 REC YDS / 2 REC TD / 15 REC YPG
Titus Mokiao-Atimalala	WR	18 REC / 240 YDS / 3 TD / 34.3 YPG
JonJon Vaughns	LB	57 TKL / 3 TFL
Isaiah Chisom	LB	49 TKL / 1 TFL
Key Lawrence	DB	34 TKL / 2 TFL
Cole Martin	DB	36 TKL / 2 TFL