Indiana vs. Penn State Prediction, Odds, Picks - November 8, 2025

The No. 2 Indiana Hoosiers (9-0) are massive, 14.5-point favorites on the road at West Shore Home Field at Beaver Stadium against the Penn State Nittany Lions (3-5) on Saturday, November 8, 2025. Both squads have stingy pass defenses, with the Hoosiers 16th against the pass in the nation, and the Nittany Lions 12th defending the passing game. The total has been set at 50.5 points for this matchup.

Facing the Maryland Terrapins in their last game, the Hoosiers won 55-10. Last time around, the Nittany Lions fell to the Ohio State Buckeyes, with 38-14 being the final score.

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Indiana vs. Penn State Game Information & Odds

• When: Saturday, November 8, 2025 at 12 p.m. ET
• Location: West Shore Home Field at Beaver Stadium in University Park, Pennsylvania
• TV: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

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Indiana vs. Penn State Prediction

• Pick ATS: Indiana (-14.5)
  
• Pick OU: Over (50.5)
  
• Prediction: Indiana 40, Penn State 14

Predictions are made by the Data Skrive betting model.

Learn more about the Indiana Hoosiers vs. the Penn State Nittany Lions game on FOX Sports!

Indiana vs. Penn State Betting Insights

• Based on the spread and over/under, the implied score for the game is Hoosiers 32, Nittany Lions 18.
• The Hoosiers have an 87.0% chance to win this contest per the moneyline's implied probability. The Nittany Lions have a 17.1% implied probability.
• Indiana is 6-3-0 ATS this season.
• Penn State has covered just once in eight games with a spread this season.

Indiana vs. Penn State: Head-to-Head

• Penn State holds a 3-0 record against Indiana in their last three matchups.
• The Nittany Lions own a 2-1 record ATS in those games, while the two teams have gone over the total on two occasions.
• Indiana has been outpaced by 64 points in its last three tilts against Penn State.

Indiana vs. Penn State: 2025 Stats Comparison

Indiana 2025 Key Players

Penn State 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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