Indiana vs. Iowa Prediction, Odds, Picks - September 27, 2025

Indiana vs. Iowa Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET
Data Skrive

The No. 11 Indiana Hoosiers (4-0) take the second-ranked scoring offense in college football into a matchup with the Iowa Hawkeyes (3-1), who have the No. 24 scoring defense, on Saturday, September 27, 2025. The Hoosiers are 8.5-point favorites. The over/under is 47.5 for this matchup.

Last time around, the Hoosiers defeated the Illinois Fighting Illini, with 63-10 being the final score. Facing the Rutgers Scarlet Knights in their last contest, the Hawkeyes won 38-28.

Keep up with college football all season on FOX Sports.

Indiana vs. Iowa Game Information & Odds

  • When: Saturday, September 27, 2025 at 3:30 p.m. ET
  • Location: Kinnick Stadium in Iowa City, Iowa
  • TV: Peacock
  • Live Box Score on FOX Sports
Indiana vs Iowa Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite Spread (Odds) Favorite Moneyline Underdog Moneyline Total Over Moneyline Under Moneyline
Indiana -8.5 (-113) -339 +269 47.5 -110 -110

Indiana vs. Iowa Prediction

  • Pick ATS: Indiana (-8.5)
  • Pick OU: Over (47.5)
  • Prediction: Indiana 48, Iowa 6

Predictions are made by the Data Skrive betting model.

Learn more about the Indiana Hoosiers vs. the Iowa Hawkeyes game on FOX Sports!

Indiana vs. Iowa Betting Insights

  • Per the spread and over/under, the implied score for the matchup is Hoosiers 28, Hawkeyes 20.
  • The Hoosiers have a 77.2% chance to claim victory in this contest based on the moneyline's implied probability. The Hawkeyes have a 27.1% implied probability.
  • Indiana is 3-1-0 ATS this season.
  • Iowa has a record of 2-1-1 against the spread this season.

Indiana vs. Iowa: 2025 Stats Comparison

Indiana Iowa
Off. Points per Game (Rank) 54.8 (2) 33 (39)
Def. Points per Game (Rank) 8.3 (7) 14.5 (31)
Turnovers Allowed (Rank) 1 (5) 2 (17)
Turnovers Forced (Rank) 6 (27) 2 (116)

Indiana 2025 Key Players

Name Position Stats
Fernando Mendoza QB 975 YDS (76.8%) / 14 TD / 0 INT
76 RUSH YDS / 2 RUSH TD / 19 RUSH YPG
Omar Cooper Jr. WR 19 REC / 377 YDS / 5 TD / 94.3 YPG
Elijah Sarratt WR 24 REC / 256 YDS / 5 TD / 64 YPG
Khobie Martin RB 222 YDS / 4 TD / 74 YPG / 8.9 YPC
Isaiah Jones LB 11 TKL / 6 TFL / 3 SACK
Louis Moore DB 17 TKL / 2 TFL / 2 INT / 2 PD
Tyrique Tucker DL 11 TKL / 4 TFL / 3 SACK
Mario Landino DL 9 TKL / 2 TFL / 3 SACK

Iowa 2025 Key Players

Name Position Stats
Mark Gronowski QB 492 YDS (60.5%) / 3 TD / 1 INT
143 RUSH YDS / 6 RUSH TD / 35.8 RUSH YPG
Kaden Wetjen WR 4 REC / 26 YDS / 1 TD / 8.7 YPG
Xavier Williams RB 186 YDS / 1 TD / 62 YPG / 7.2 YPC
Jaziun Patterson RB 198 YDS / 0 TD / 49.5 YPG / 5.8 YPC
Jaden Harrell LB 29 TKL / 1 TFL / 1 SACK
Max Llewellyn DL 9 TKL / 5 TFL / 4 SACK
Karson Sharar LB 26 TKL / 1 TFL / 1 SACK
Zach Lutmer DB 21 TKL / 2 TFL / 1 SACK

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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