Indiana vs. Iowa Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

Data Skrive

The No. 11 Indiana Hoosiers (4-0) take the second-ranked scoring offense in college football into a matchup with the Iowa Hawkeyes (3-1), who have the No. 24 scoring defense, on Saturday, September 27, 2025. The Hoosiers are 8.5-point favorites. The over/under is 47.5 for this matchup.

Last time around, the Hoosiers defeated the Illinois Fighting Illini, with 63-10 being the final score. Facing the Rutgers Scarlet Knights in their last contest, the Hawkeyes won 38-28.

Keep up with college football all season on FOX Sports.

Indiana vs. Iowa Game Information & Odds

When: Saturday, September 27, 2025 at 3:30 p.m. ET
Location: Kinnick Stadium in Iowa City, Iowa
TV: Peacock
Live Box Score on FOX Sports

Indiana vs Iowa Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Indiana	-8.5 (-113)	-339	+269	47.5	-110	-110

Indiana vs. Iowa Prediction

Pick ATS: Indiana (-8.5)
Pick OU: Over (47.5)
Prediction: Indiana 48, Iowa 6

Predictions are made by the Data Skrive betting model.

Learn more about the Indiana Hoosiers vs. the Iowa Hawkeyes game on FOX Sports!

Indiana vs. Iowa Betting Insights

Per the spread and over/under, the implied score for the matchup is Hoosiers 28, Hawkeyes 20.
The Hoosiers have a 77.2% chance to claim victory in this contest based on the moneyline's implied probability. The Hawkeyes have a 27.1% implied probability.
Indiana is 3-1-0 ATS this season.
Iowa has a record of 2-1-1 against the spread this season.

Indiana vs. Iowa: 2025 Stats Comparison

	Indiana	Iowa
Off. Points per Game (Rank)	54.8 (2)	33 (39)
Def. Points per Game (Rank)	8.3 (7)	14.5 (31)
Turnovers Allowed (Rank)	1 (5)	2 (17)
Turnovers Forced (Rank)	6 (27)	2 (116)

Indiana 2025 Key Players

Name	Position	Stats
Fernando Mendoza	QB	975 YDS (76.8%) / 14 TD / 0 INT 76 RUSH YDS / 2 RUSH TD / 19 RUSH YPG
Omar Cooper Jr.	WR	19 REC / 377 YDS / 5 TD / 94.3 YPG
Elijah Sarratt	WR	24 REC / 256 YDS / 5 TD / 64 YPG
Khobie Martin	RB	222 YDS / 4 TD / 74 YPG / 8.9 YPC
Isaiah Jones	LB	11 TKL / 6 TFL / 3 SACK
Louis Moore	DB	17 TKL / 2 TFL / 2 INT / 2 PD
Tyrique Tucker	DL	11 TKL / 4 TFL / 3 SACK
Mario Landino	DL	9 TKL / 2 TFL / 3 SACK

Iowa 2025 Key Players

Name	Position	Stats
Mark Gronowski	QB	492 YDS (60.5%) / 3 TD / 1 INT 143 RUSH YDS / 6 RUSH TD / 35.8 RUSH YPG
Kaden Wetjen	WR	4 REC / 26 YDS / 1 TD / 8.7 YPG
Xavier Williams	RB	186 YDS / 1 TD / 62 YPG / 7.2 YPC
Jaziun Patterson	RB	198 YDS / 0 TD / 49.5 YPG / 5.8 YPC
Jaden Harrell	LB	29 TKL / 1 TFL / 1 SACK
Max Llewellyn	DL	9 TKL / 5 TFL / 4 SACK
Karson Sharar	LB	26 TKL / 1 TFL / 1 SACK
Zach Lutmer	DB	21 TKL / 2 TFL / 1 SACK