Illinois vs. Duke Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 9:04 a.m. ET

FOX Sports

Oddsmakers expect a tight game when the No. 11 Illinois Fighting Illini (1-0) take on the Duke Blue Devils (1-0) as only 2.5-point favorites on Saturday, September 6, 2025. An over/under of 49.5 is set in the game.

In their last action, the Fighting Illini won against the Western Illinois Leathernecks, 52-3. Facing the Elon Phoenix in their last game, the Blue Devils won 45-17.

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Illinois vs. Duke Game Information & Odds

When: Saturday, September 6, 2025 at 12 p.m. ET
Location: Brooks Field at Wallace Wade Stadium in Wilmington, North Carolina
TV: ESPN
Live Box Score on FOX Sports

Illinois vs Duke Betting Information updated as of September 6, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Illinois	-2.5 (-111)	-137	+115	49.5	-110	-117

Illinois vs. Duke Prediction

Pick ATS: Illinois (-2.5)
Pick OU: Over (49.5)
Prediction: Illinois 28, Duke 23

Predictions are made by the Data Skrive betting model.

Learn more about the Illinois Fighting Illini vs. the Duke Blue Devils game on FOX Sports!

Illinois vs. Duke Betting Insights

Per the spread and over/under, the implied score for the game is Fighting Illini 26, Blue Devils 24.
The Fighting Illini have a 57.8% chance to win this meeting based on the moneyline's implied probability. The Blue Devils hold a 46.5% implied probability.
Illinois has compiled a perfect 1-0-0 record against the spread this season.
Duke has not won against the spread this season in one chances.

Illinois vs. Duke: 2025 Stats Comparison

	Illinois	Duke
Off. Points per Game (Rank)	52 (20)	45 (31)
Def. Points per Game (Rank)	3 (11)	17 (66)
Turnovers Allowed (Rank)	0 (1)	1 (55)
Turnovers Forced (Rank)	1 (51)	0 (94)

Illinois 2025 Key Players

Name	Position	Stats
Aidan Laughery	RB	101 YDS / 2 TD / 101 YPG / 11.2 YPC 2 REC / 22 REC YDS / 0 REC TD / 22 REC YPG
Luke Altmyer	QB	217 YDS (81%) / 3 TD / 0 INT
Hank Beatty	WR	5 REC / 108 YDS / 0 TD / 108 YPG
Justin Bowick	WR	3 REC / 23 YDS / 2 TD / 23 YPG
Gabe Jacas	LB	5 TKL / 1 TFL / 2 SACK
Tomiwa Durojaiye	DL	4 TKL / 1 TFL / 1 SACK
Gentle Hunt	DL	4 TKL / 1 TFL / 0.5 SACK
Kaleb Patterson	DB	2 TKL / 0 TFL

Duke 2025 Key Players

Name	Position	Stats
Darian Mensah	QB	389 YDS (79.4%) / 3 TD / 0 INT
Sahmir Hagans	WR	5 REC / 54 YDS / 2 TD / 54 YPG
Sean Brown	WR	6 REC / 93 YDS / 0 TD / 93 YPG
Cooper Barkate	WR	5 REC / 117 YDS / 0 TD / 117 YPG
Vincent Anthony Jr.	DL	6 TKL / 1 TFL / 1 SACK
Jaiden Francois	LB	10 TKL / 0 TFL / 0.5 SACK
Tre Freeman	LB	6 TKL / 1 TFL / 0.5 SACK
Josiah Green	DL	3 TKL / 1 TFL / 1 SACK