Houston vs. West Virginia Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 9:04 a.m. ET

Data Skrive

The No. 22 Houston Cougars (7-1) host the West Virginia Mountaineers (2-6) on Saturday, November 1, 2025 in a matchup between Big 12 foes at TDECU Stadium. West Virginia is a 13.5-point underdog. The contest has a 48.5-point over/under.

The Cougars beat the Arizona State Sun Devils, 24-16, in their most recent contest. The Mountaineers lost against the TCU Horned Frogs in their last game, 23-17.

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Houston vs. West Virginia Game Information & Odds

When: Saturday, November 1, 2025 at 12 p.m. ET
Location: TDECU Stadium in Houston, Texas
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Houston vs West Virginia Betting Information updated as of November 1, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Houston	-13.5 (-109)	-549	+402	48.5	-108	-112

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Houston vs. West Virginia Prediction

Pick ATS: Houston (-13.5)
Pick OU: Over (48.5)
Prediction: Houston 35, West Virginia 16

Predictions are made by the Data Skrive betting model.

Learn more about the Houston Cougars vs. the West Virginia Mountaineers game on FOX Sports!

Houston vs. West Virginia Betting Insights

Per the spread and over/under, the implied score for the tilt is Cougars 31, Mountaineers 18.
The Cougars have an 84.6% chance to collect the win in this contest per the moneyline's implied probability. The Mountaineers have a 19.9% implied probability.
Houston has won six games against the spread this season, while failing to cover twice.
West Virginia has covered four times in eight matchups with a spread this year.

Houston vs. West Virginia: 2025 Stats Comparison

	Houston	West Virginia
Off. Points per Game (Rank)	28.8 (64)	20.5 (115)
Def. Points per Game (Rank)	18.6 (28)	29.9 (105)
Turnovers Allowed (Rank)	4 (3)	12 (100)
Turnovers Forced (Rank)	8 (85)	12 (32)

Houston 2025 Key Players

Name	Position	Stats
Conner Weigman	QB	1,581 YDS (63.7%) / 12 TD / 2 INT 357 RUSH YDS / 8 RUSH TD / 44.6 RUSH YPG
Dean Connors	RB	586 YDS / 4 TD / 73.3 YPG / 4.3 YPC 18 REC / 130 REC YDS / 1 REC TD / 16.3 REC YPG
Amare Thomas	WR	30 REC / 535 YDS / 4 TD / 66.9 YPG
Tanner Koziol	TE	43 REC / 450 YDS / 4 TD / 56.3 YPG
Jalen Garner	LB	38 TKL / 1 TFL / 2 SACK
Eddie Walls III	DL	17 TKL / 5 TFL / 5.5 SACK
Wrook Brown	DB	21 TKL / 4 TFL / 2.5 SACK / 1 INT
Latreveon McCutchin	LB	24 TKL / 1 TFL / 1 SACK / 1 INT

West Virginia 2025 Key Players

Name	Position	Stats
Cam Vaughn	WR	27 REC / 419 YDS / 3 TD / 52.4 YPG
Nicco Marchiol	QB	720 YDS (67.3%) / 2 TD / 2 INT 56 RUSH YDS / 1 RUSH TD / 14 RUSH YPG
Scotty Fox Jr.	QB	466 YDS (59.1%) / 3 TD / 2 INT 80 RUSH YDS / 1 RUSH TD / 13.3 RUSH YPG
Khalil Wilkins	QB	176 YDS (48.4%) / 1 TD / 2 INT 243 RUSH YDS / 2 RUSH TD / 48.6 RUSH YPG
Fred Perry	DB	48 TKL / 3 TFL / 2 SACK
Chase Wilson	LB	32 TKL / 4 TFL / 3 SACK / 2 INT
Darrian Lewis	DB	47 TKL / 0 TFL / 2 INT / 2 PD
Reid Carrico	LB	37 TKL / 3 TFL / 1.5 SACK