College Football Upsets from Week 15

There were multiple upsets during Week 15 of the 2025 college football campaign -- see below for a complete list of which teams defied the odds.

Check out the full college football schedule on FOX Sports.

Biggest College Football Upsets This Week

Illinois State 29, North Dakota State 28

• Home Team: North Dakota State
• Spread Favorite: North Dakota State (-23.5)
• Moneyline: North Dakota State -3226, Illinois State +1400
• O/U: Over (51.5)
• Box Score

South Dakota 47, Mercer 0

• Home Team: Mercer
• Spread Favorite: Mercer (-6)
• Moneyline: Mercer -218, South Dakota +180
• O/U: Under (54.5)
• Box Score

Villanova 14, Lehigh 7

• Home Team: Lehigh
• Spread Favorite: Lehigh (-4)
• Moneyline: Lehigh -180, Villanova +150
• O/U: Under (49.5)
• Box Score

Yale 43, Youngstown State 42

• Home Team: Youngstown State
• Spread Favorite: Youngstown State (-4)
• Moneyline: Youngstown State -185, Yale +154
• O/U: Over (61.5)
• Box Score

Illinois State 21, Southeastern Louisiana 3

• Home Team: Southeastern Louisiana
• Spread Favorite: Southeastern Louisiana (-2.5)
• Moneyline: Southeastern Louisiana -135, Illinois State +114
• O/U: Under (54.5)
• Box Score

Villanova 14, Harvard 7

• Home Team: Villanova
• Spread Favorite: Harvard (-2.5)
• Moneyline: Harvard -130, Villanova +110
• O/U: Under (55.5)
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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