Arizona vs. Houston Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 9:04 a.m. ET

FOX Sports

Oddsmakers project a competitive game between Big 12 rivals when the Arizona Wildcats (4-2) visit the Houston Cougars (5-1) on Saturday, October 18, 2025 at TDECU Stadium. Houston is a 1.5-point underdogs. The over/under is 47.5 for the game.

The Wildcats lost against the BYU Cougars in their last game, 33-27. In their last contest, the Cougars won against the Oklahoma State Cowboys, 39-17.

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Arizona vs. Houston Game Information & Odds

When: Saturday, October 18, 2025 at 12 p.m. ET
Location: TDECU Stadium in Houston, Texas
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Arizona vs Houston Betting Information updated as of October 18, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Arizona	-1.5 (-105)	-114	-105	47.5	-106	-114

Arizona vs. Houston Prediction

Pick ATS: Houston (+1.5)
Pick OU: Over (47.5)
Prediction: Houston 27, Arizona 23

Predictions are made by the Data Skrive betting model.

Learn more about the Arizona Wildcats vs. the Houston Cougars game on FOX Sports!

Arizona vs. Houston Betting Insights

Per the spread and over/under, the implied score for the tilt is Wildcats 24, Cougars 23.
The Wildcats have a 53.3% chance to win this meeting based on the moneyline's implied probability. The Cougars have a 51.2% implied probability.
Arizona has won three games against the spread this season, while failing to cover twice.
Houston has compiled a 4-2-0 ATS record so far this year.

Arizona vs. Houston: 2025 Stats Comparison

	Arizona	Houston
Off. Points per Game (Rank)	32.2 (57)	29.2 (68)
Def. Points per Game (Rank)	18.5 (25)	17.5 (22)
Turnovers Allowed (Rank)	8 (76)	4 (11)
Turnovers Forced (Rank)	13 (5)	8 (55)

Arizona 2025 Key Players

Name	Position	Stats
Noah Fifita	QB	1,560 YDS (62.7%) / 15 TD / 4 INT 60 RUSH YDS / 3 RUSH TD / 10 RUSH YPG
Ismail Mahdi	RB	403 YDS / 1 TD / 67.2 YPG / 5.7 YPC 10 REC / 74 REC YDS / 1 REC TD / 14.8 REC YPG
Jayin Whatley	WR	25 REC / 328 YDS / 3 TD / 54.7 YPG
Kris Hutson	WR	20 REC / 262 YDS / 2 TD / 65.5 YPG
Dalton Johnson	DB	28 TKL / 1 TFL / 1 SACK / 1 INT
Genesis Smith	DB	23 TKL / 0 TFL / 1 INT / 4 PD
Jay'Vion Cole	DB	12 TKL / 2 TFL / 1 SACK / 2 INT
Chase Kennedy	LB	10 TKL / 3 TFL / 2 SACK

Houston 2025 Key Players

Name	Position	Stats
Conner Weigman	QB	1,216 YDS (61.5%) / 8 TD / 2 INT 148 RUSH YDS / 5 RUSH TD / 24.7 RUSH YPG
Dean Connors	RB	438 YDS / 4 TD / 73 YPG / 4.6 YPC 13 REC / 75 REC YDS / 1 REC TD / 12.5 REC YPG
Amare Thomas	WR	23 REC / 441 YDS / 2 TD / 73.5 YPG
Tanner Koziol	TE	30 REC / 310 YDS / 2 TD / 51.7 YPG
Jalen Garner	LB	27 TKL / 1 TFL / 2 SACK
Latreveon McCutchin	LB	19 TKL / 1 TFL / 1 SACK / 1 INT
Corey Platt Jr.	LB	15 TKL / 2 TFL / 2.5 SACK
Marc Stampley II	DB	16 TKL / 1 TFL / 1 SACK / 1 INT