Alabama vs. LSU Prediction, Odds, Picks - November 8, 2025

Updated Nov. 8, 2025 3:04 p.m. ET

Data Skrive

The No. 4 Alabama Crimson Tide (7-1), who have college football's 19th-ranked scoring defense, take on the LSU Tigers (5-3) and their 20th-ranked scoring defense on Saturday, November 8, 2025. The Crimson Tide are massive, 10.5-point favorites. The over/under is set at 49.5.

The Crimson Tide beat the South Carolina Gamecocks, 29-22, in their last game. Last time around, the Tigers fell to the Texas A&M Aggies, with 49-25 being the final score.

Keep up with college football all season on FOX Sports.

Alabama vs. LSU Game Information & Odds

When: Saturday, November 8, 2025 at 7:30 p.m. ET
Location: Bryant-Denny Stadium in Tuscaloosa, Alabama
TV: ABC
Live Box Score on FOX Sports

Alabama vs LSU Betting Information updated as of November 8, 2025, 1:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Alabama	-10.5 (-110)	-418	+321	49.5	-110	-110

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Alabama vs. LSU Prediction

Pick ATS: Alabama (-10.5)
Pick OU: Under (49.5)
Prediction: Alabama 31, LSU 16

Predictions are made by the Data Skrive betting model.

Learn more about the Alabama Crimson Tide vs. the LSU Tigers game on FOX Sports!

Alabama vs. LSU Betting Insights

Based on the spread and over/under, the implied score for the game is Crimson Tide 30, Tigers 20.
The Crimson Tide have an 80.7% chance to collect the win in this meeting based on the moneyline's implied probability. The Tigers have a 23.8% implied probability.
Alabama is 5-3-0 ATS this season.
LSU has put together a 3-5-0 record against the spread this season.

Alabama vs. LSU: Head-to-Head

Over their last four meetings, Alabama has collected three wins versus LSU.
The two teams have gone over the point total on two occasions while sharing a split 2-2 record in their meetings against the spread.
Over their last four head-to-head contests, Alabama has racked up 135 points, while LSU has accumulated 87.

Alabama vs. LSU: 2025 Stats Comparison

	Alabama	LSU
Off. Points per Game (Rank)	34.4 (43)	25.5 (98)
Def. Points per Game (Rank)	18.3 (16)	18.9 (18)
Turnovers Allowed (Rank)	5 (3)	8 (24)
Turnovers Forced (Rank)	14 (29)	12 (46)

Alabama 2025 Key Players

Name	Position	Stats
Ty Simpson	QB	2,184 YDS (67.8%) / 20 TD / 1 INT 79 RUSH YDS / 2 RUSH TD / 9.9 RUSH YPG
Germie Bernard	WR	38 REC / 526 YDS / 6 TD / 65.8 YPG
Ryan Williams	WR	33 REC / 495 YDS / 3 TD / 70.7 YPG
Isaiah Horton	WR	22 REC / 272 YDS / 5 TD / 38.9 YPG
Justin Jefferson	LB	47 TKL / 3 TFL / 2 SACK / 1 INT
Yhonzae Pierre	LB	29 TKL / 7 TFL / 4 SACK
Bray Hubbard	DB	39 TKL / 1 TFL / 3 INT / 3 PD
Deontae Lawson	LB	37 TKL / 0 TFL

LSU 2025 Key Players

Name	Position	Stats
Garrett Nussmeier	QB	1,804 YDS (65.9%) / 12 TD / 5 INT -44 RUSH YDS / 1 RUSH TD / -5.5 RUSH YPG
Caden Durham	RB	378 YDS / 2 TD / 54 YPG / 4.8 YPC
Zavion Thomas	WR	20 REC / 267 YDS / 3 TD / 33.4 YPG
Trey'Dez Green	TE	21 REC / 264 YDS / 4 TD / 44 YPG
Adari Haulcy	DB	48 TKL / 0 TFL / 2 INT / 2 PD
West Weeks	LB	46 TKL / 4 TFL / 1.5 SACK
Tamarcus Cooley	DB	37 TKL / 0 TFL / 2 INT / 2 PD
Harold Perkins	LB	27 TKL / 2 TFL / 2 SACK / 1 INT