Xavier vs. Santa Clara Prediction, How to Watch, Odds, Channel - Nov 10

The Xavier Musketeers (2-0) play the Santa Clara Broncos (2-0) on Monday, November 10, 2025 at 8:30 p.m. ET. The matchup airs on FS1.

The Musketeers are a 3.5-point favorite against the Broncos when the Musketeers and Broncos hit the court. The game features an over/under of 154.5.

Continue reading to get the details before placing bets on the Xavier-Santa Clara game.

Xavier vs. Santa Clara How to Watch & Odds

• When: Monday, November 10, 2025 at 8:30 p.m. ET
• Where: Cintas Center in Cincinnati, Ohio
• TV: FS1
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

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Xavier vs. Santa Clara Prediction

• Pick ATS: Santa Clara (+3.5)
  
• Pick OU: Under (154.5)
  
• Prediction: Xavier 71, Santa Clara 70

Learn more about the Xavier Musketeers vs. the Santa Clara Broncos game on FOX Sports!

Xavier vs. Santa Clara Betting Insights

Betting Line Implied Predictions

• Based on the spread and over/under, the implied score for the matchup is Musketeers 79, Broncos 76.
• The Musketeers have a 62.7% chance to claim victory in this contest based on the moneyline's implied probability.
• The Broncos hold a 41.5% implied probability to come out on top.

Key Spread Facts

• Xavier compiled a 19-15-0 ATS record last year.
• Santa Clara covered 17 times in 32 games with a spread last season.
• Xavier was favored by 3.5 points or more 16 times last season, and covered the spread in nine of those games.
• Santa Clara covered the spread five times last year (5-3 ATS) when playing as at least a 3.5-point underdog.

Key Total Facts

• The Musketeers games had more than 154.5 points on 10 occasions last season.
• Broncos games finished with more than 154.5 points scored 16 times last year.
• These two teams scored a combined average of 160 points per game last season, higher than the total for this matchup by 5.5 points.

Key Moneyline Facts

• Xavier won all 21 of the games in which it was the moneyline favorite last season.
• Santa Clara won three of the 10 games it played as underdogs last season.
• Xavier won all 16 games it played as a moneyline favorite with odds of -168 or shorter last year.
• Santa Clara had a record of 3-5 when it was set as the underdog by +141 or more by sportsbooks last season.

Xavier vs. Santa Clara: 2024-25 Stats Comparison

Xavier 2024-25 Top Performers

Santa Clara 2024-25 Top Performers

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Big East

Xavier Musketeers

Santa Clara Broncos