Villanova vs. DePaul Prediction, How to Watch, Odds, Channel - Dec 31

Updated Dec. 31, 2025 8:27 p.m. ET

Data Skrive

The Villanova Wildcats (10-2, 1-0 Big East) will attempt to extend a three-game win streak when they host the DePaul Blue Demons (8-5, 0-2 Big East) on Wednesday, December 31, 2025 at The William B. Finneran Pavilion. The game airs at 6 p.m. ET on FS1.

The Wildcats are a double-digit favorite against the Blue Demons when the Wildcats and the Blue Demons meet. The Wildcats are favored by 12.5 points. The game features an over/under of 139.

Keep reading to get everything you need to know before placing bets on the Villanova-DePaul game.

Villanova vs. DePaul How to Watch & Odds

When: Wednesday, December 31, 2025 at 6 p.m. ET
Where: The William B. Finneran Pavilion in Bryn Mawr, Pennsylvania
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Wildcats vs Blue Demons Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Wildcats	-12.5	-110	-110	139	-110	-110	-952	+622

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Villanova vs. DePaul Prediction

Pick ATS: Villanova (-12.5)
Pick OU: Over (139)
Prediction: Villanova 79, DePaul 66

Learn more about the Villanova Wildcats vs. the DePaul Blue Demons game on FOX Sports!

Villanova vs. DePaul Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the game is Wildcats 76, Blue Demons 63.
The Wildcats have a 90.5% chance to collect the win in this meeting per the moneyline's implied probability.
The Blue Demons hold a 13.9% implied probability to win.

Key Spread Facts

Villanova has compiled a 9-3-0 ATS record so far this year.
DePaul has put together a 7-6-0 record against the spread this year.
Villanova has an ATS record of 5-1 when playing as at least 12.5-point favorites this season.
DePaul has been an underdog by 12.5 points or more two times this season, and covered the spread in one of those matchups.

Key Total Facts

Eight times so far this season, the Wildcats and their opponent have combined to score more than 139 points.
Blue Demons games have finished with over 139 points scored eight times this year.
These teams score 153.4 points per game combined, higher than the over/under for this matchup by 14.4.

Key Moneyline Facts

Villanova has won all eight games when listed as the moneyline favorite this season.
DePaul has entered the game as underdogs five times this season and won once.
Villanova has won all five games it played as a moneyline favorite with odds of -952 or shorter.
DePaul has played as an underdog of +622 or more twice this season and lost both games.

Villanova vs. DePaul: Recent Results

Wildcats vs Blue Demons Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
2/5/2025	Wildcats	-6.5	141.5	-270	+218	59-49 VILL
1/4/2025	Wildcats	-9	146.5	-448	+343	100-56 VILL

Villanova vs. DePaul: 2025-26 Stats Comparison

	Villanova	DePaul
Points Scored Per Game (Rank)	78.7 (156)	74.7 (249)
Points Allowed (Rank)	66.9 (53)	69 (88)
Rebounds (Rank)	10.7 (97)	8.5 (273)
3pt Made (Rank)	10.6 (30)	7.4 (238)
Assists (Rank)	15.8 (108)	16.2 (93)
Turnovers (Rank)	9.8 (40)	11.3 (157)

Villanova 2025-26 Key Players

Wildcats Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Bryce Lindsay	12	16.6	2.2	2.6	0.7	0	3.2
Acaden Lewis	12	12.3	3.8	5	1.6	0	0.8
Duke Brennan	11	12	11.4	1.8	0.8	0.5	0
Matthew Hodge	12	10.7	4.3	1	0.6	0.7	1.8
Tyler Perkins	12	10.2	4.8	1.7	0.9	0.2	1.7

DePaul 2025-26 Key Players

Blue Demons Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
CJ Gunn	13	13.8	3.2	1.8	1.2	0.8	1.5
N.J. Benson	13	10.9	6.7	1.2	0.1	1	0
Layden Blocker	13	10.9	2.2	3.7	1.9	0.1	0.8
Kaleb Banks	13	8.2	3.2	0.8	0.4	0.3	1.2
RJ Smith	13	7.8	2.5	2.2	0.5	0.2	1.3