USC vs. Northwestern Prediction, How to Watch, Odds, Channel - Jan 21

Updated Jan. 22, 2026 1:28 a.m. ET

Data Skrive

The Northwestern Wildcats (8-10, 0-7 Big Ten) will visit the USC Trojans (14-4, 3-4 Big Ten) after losing four straight road games. The contest starts at 11 p.m. ET on Wednesday, January 21, 2026.

The Trojans take the court as 6.5-point favorites against the Wildcats. The matchup's point total is set at 149.5.

Keep scrolling to get the details before wagering on the USC-Northwestern contest.

USC vs. Northwestern How to Watch & Odds

When: Wednesday, January 21, 2026 at 11 p.m. ET
Where: Galen Center in Los Angeles, California
TV: Big Ten Network
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Trojans vs Wildcats Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Trojans	-6.5	-112	-108	149.5	-110	-110	-302	+242

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USC vs. Northwestern Prediction

Pick ATS: Northwestern (+6.5)
Pick OU: Over (149.5)
Prediction: USC 79, Northwestern 75

Learn more about the USC Trojans vs. the Northwestern Wildcats game on FOX Sports!

USC vs. Northwestern Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the game is Trojans 78, Wildcats 72.
The Trojans have a 75.1% chance to win this game based on the moneyline's implied probability.
The Wildcats sit with a 29.2% implied probability to come out on top.

Key Spread Facts

USC has covered nine times in 17 matchups with a spread this season.
Northwestern has covered five times in 18 games with a spread this year.
USC has an ATS record of 5-4 when playing as at least 6.5-point favorites this season.
Northwestern has covered the spread once this season (1-2 ATS) when playing as at least 6.5-point underdogs.

Key Total Facts

Trojans games have finished with more than 149.5 points 12 times so far this year.
There have been 10 Wildcats games this season with more than 149.5 points scored.
The total for this matchup is 149.5 points, 11.2 fewer than the combined scoring average of the two teams.

Key Moneyline Facts

USC has won 92.3% of its games this season when the moneyline favorite (12-1).
This season, Northwestern has been listed as the underdog in six games and failed to win any of those contests.
USC has won all eight games it played as a moneyline favorite with odds of -302 or shorter.
Northwestern has not won as an underdog of +242 or more on the moneyline this season in three games with those odds or longer.

USC vs. Northwestern: Recent Results

Trojans vs Wildcats Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
2/4/2025	Wildcats	-3.5	138	-173	+144	77-75 NW

USC vs. Northwestern: 2025-26 Stats Comparison

	USC	Northwestern
Points Scored Per Game (Rank)	83.4 (63)	77.3 (171)
Points Allowed (Rank)	75.8 (236)	71.9 (128)
Rebounds (Rank)	9.7 (165)	8.3 (285)
3pt Made (Rank)	6.7 (291)	6.3 (316)
Assists (Rank)	16.5 (62)	17.8 (24)
Turnovers (Rank)	12.5 (288)	8.2 (1)

USC 2025-26 Key Players

Trojans Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Rodney Rice	6	20.3	3.3	6.0	1.2	0.2	2.5
Chad Baker-Mazara	18	18.9	4.5	3.2	0.8	1.4	2.1
Ezra Ausar	18	16.1	6.0	1.8	0.9	0.4	0.0
Jacob Cofie	18	10.0	6.8	1.8	1.1	1.7	0.6
Jaden Brownell	18	7.3	2.5	0.6	0.4	0.4	1.2

Northwestern 2025-26 Key Players

Wildcats Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Nick Martinelli	17	23.7	6.8	1.5	0.6	0.4	1.4
Arrinten Page	17	12.8	5.8	2.2	0.9	1.2	0.5
Jayden Reid	18	11.6	1.9	5.4	0.9	0.1	0.9
Tre Singleton	18	7.4	4.7	1.5	0.6	0.6	0.3
Angelo Ciaravino	17	6.4	4.1	1.6	0.5	0.8	0.3