UConn vs. DePaul Prediction, How to Watch, Odds, Channel - Dec 21

Updated Dec. 20, 2025 8:27 p.m. ET

Data Skrive

The DePaul Blue Demons (8-4, 0-1 Big East) will attempt to extend a four-game home win streak when they square off against the No. 5 UConn Huskies (11-1, 1-0 Big East) on Sunday, December 21, 2025 at Wintrust Arena. The contest airs at 4:30 p.m. ET on FS1.

The Huskies hit the court as double-digit favorites against the Blue Demons. The Huskies are favored by 14.5 points. The over/under for the matchup is 136.5.

Continue scrolling to get all the information ahead of placing bets on the UConn-DePaul matchup.

UConn vs. DePaul How to Watch & Odds

When: Sunday, December 21, 2025 at 4:30 p.m. ET
Where: Wintrust Arena in Chicago, Illinois
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Huskies vs Blue Demons Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Huskies	-14.5	-110	-110	136.5	-110	-109	-1408	+805

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UConn vs. DePaul Prediction

Pick ATS: DePaul (+14.5)
Pick OU: Over (136.5)
Prediction: UConn 78, DePaul 64

Learn more about the UConn Huskies vs. the DePaul Blue Demons game on FOX Sports!

UConn vs. DePaul Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the encounter is Huskies 76, Blue Demons 61.
The Huskies have a 93.4% chance to claim victory in this game based on the moneyline's implied probability.
The Blue Demons hold an 11.0% implied probability to win.

Key Spread Facts

UConn has covered four times in 12 chances against the spread this season.
DePaul has won seven games against the spread this season, while failing to cover five times.
UConn has covered the spread twice when favored by 14.5 points or more this season (in six opportunities).
DePaul has covered the spread when playing as at least 14.5-point underdogs in its only opportunity this season.

Key Total Facts

Seven times so far this year, the Huskies and their opponent have combined for more than 136.5 points.
Blue Demons games have gone over 136.5 points on eight occasions this year.
The over/under for this game is 136.5 points, 18.9 fewer than the scoring average of the two teams combined.

Key Moneyline Facts

UConn has been favored on the moneyline nine times this season. They've gone 8-1 in those games.
DePaul has won one of the four games it has played as underdogs this season.
UConn has won all three games it played as a moneyline favorite with odds of -1408 or shorter.
DePaul has played as an underdog of +805 or more once this season and lost that game.

UConn vs. DePaul: Recent Results

Huskies vs Blue Demons Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
1/29/2025	Huskies	-13.5	140	-1235	+749	72-61 UCONN
1/1/2025	Huskies	-11.5	145	-813	+555	81-68 UCONN

UConn vs. DePaul: 2025-26 Stats Comparison

	UConn	DePaul
Points Scored Per Game (Rank)	79.0 (146)	76.4 (213)
Points Allowed (Rank)	61.7 (6)	68.8 (83)
Rebounds (Rank)	9.1 (233)	8.6 (270)
3pt Made (Rank)	7.5 (221)	7.8 (198)
Assists (Rank)	18.4 (28)	16.9 (64)
Turnovers (Rank)	9.4 (22)	11.2 (144)

UConn 2025-26 Key Players

Huskies Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Solomon Ball	12	15.4	3.5	1.5	0.7	0.3	2.0
Tarris Reed Jr.	7	14.6	7.0	1.7	1.0	2.1	0.0
Alex Karaban	12	13.0	5.3	2.1	1.0	1.1	1.8
Braylon Mullins	6	9.5	2.8	1.0	0.5	0.3	1.3
Eric Reibe	12	8.8	4.6	0.3	0.3	1.5	0.3

DePaul 2025-26 Key Players

Blue Demons Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
CJ Gunn	12	14.3	3.4	1.8	1.2	0.8	1.6
N.J. Benson	12	11.3	6.6	1.3	0.1	1.1	0.0
Layden Blocker	12	10.9	2.2	3.8	2.0	0.0	0.8
Kaleb Banks	12	8.7	3.3	0.8	0.4	0.3	1.3
RJ Smith	12	7.8	2.7	2.2	0.5	0.2	1.3