UConn vs. DePaul Prediction, How to Watch, Odds, Channel - Dec 21

Updated Dec. 21, 2025 3:27 p.m. ET

Data Skrive

The No. 5 UConn Huskies (11-1, 1-0 Big East) will try to extend a seven-game win streak when they visit the DePaul Blue Demons (8-4, 0-1 Big East) on Sunday, December 21, 2025 at Wintrust Arena. The game airs at 4:30 p.m. ET on FS1.

The Huskies hit the court as double-digit favorites against the Blue Demons. The Huskies are favored by 12.5 points. The matchup features an over/under of 134.5.

Continue scrolling to get the details before placing bets on the UConn-DePaul game.

UConn vs. DePaul How to Watch & Odds

When: Sunday, December 21, 2025 at 4:30 p.m. ET
Where: Wintrust Arena in Chicago, Illinois
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Huskies vs Blue Demons Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Huskies	-12.5	-111	-109	134.5	-111	-109	-1042	+653

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UConn vs. DePaul Prediction

Pick ATS: UConn (-12.5)
Pick OU: Over (134.5)
Prediction: UConn 78, DePaul 64

Learn more about the UConn Huskies vs. the DePaul Blue Demons game on FOX Sports!

UConn vs. DePaul Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the matchup is Huskies 74, Blue Demons 61.
The Huskies have a 91.2% chance to claim victory in this matchup based on the moneyline's implied probability.
The Blue Demons have a 13.3% implied probability to come out on top.

Key Spread Facts

UConn has compiled a 4-8-0 ATS record so far this year.
DePaul has covered seven times in 12 chances against the spread this season.
UConn has covered the spread twice this season (2-5 ATS) when playing as at least 12.5-point favorites.
DePaul has been an underdog by 12.5 points or more once this season, and covered the spread.

Key Total Facts

Eight times so far this season, the Huskies and their opponent have combined to score more than 134.5 points.
Blue Demons games have had over 134.5 points 10 times this season.
The total for this matchup is 134.5 points, 20.9 fewer than the combined scoring average of the two teams.

Key Moneyline Facts

UConn has won eight of nine games when listed as the moneyline favorite this season (88.9%).
This season, DePaul has been the underdog four times and won one of those games.
UConn has won all four games it played as a moneyline favorite with odds of -1042 or shorter.
DePaul has played as an underdog of +653 or more once this season and lost that game.

UConn vs. DePaul: Recent Results

Huskies vs Blue Demons Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
1/29/2025	Huskies	-13.5	140	-1235	+749	72-61 UCONN
1/1/2025	Huskies	-11.5	145	-813	+555	81-68 UCONN

UConn vs. DePaul: 2025-26 Stats Comparison

	UConn	DePaul
Points Scored Per Game (Rank)	79.0 (145)	76.4 (210)
Points Allowed (Rank)	61.7 (6)	68.8 (85)
Rebounds (Rank)	9.1 (235)	8.6 (270)
3pt Made (Rank)	7.5 (223)	7.8 (197)
Assists (Rank)	18.4 (26)	16.9 (63)
Turnovers (Rank)	9.4 (23)	11.2 (145)

UConn 2025-26 Key Players

Huskies Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Solomon Ball	12	15.4	3.5	1.5	0.7	0.3	2.0
Tarris Reed Jr.	7	14.6	7.0	1.7	1.0	2.1	0.0
Alex Karaban	12	13.0	5.3	2.1	1.0	1.1	1.8
Braylon Mullins	6	9.5	2.8	1.0	0.5	0.3	1.3
Eric Reibe	12	8.8	4.6	0.3	0.3	1.5	0.3

DePaul 2025-26 Key Players

Blue Demons Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
CJ Gunn	12	14.3	3.4	1.8	1.2	0.8	1.6
N.J. Benson	12	11.3	6.6	1.3	0.1	1.1	0.0
Layden Blocker	12	10.9	2.2	3.8	2.0	0.0	0.8
Kaleb Banks	12	8.7	3.3	0.8	0.4	0.3	1.3
RJ Smith	12	7.8	2.7	2.2	0.5	0.2	1.3