Michigan State vs. East Carolina Prediction, How to Watch, Odds, Channel - Nov 25

The No. 11 Michigan State Spartans (5-0) will host the East Carolina Pirates (2-3) after winning four straight home games. The matchup starts at 1 p.m. ET on Tuesday, November 25, 2025.

The Spartans head into their game against the Pirates as huge favorites. The Spartans are favored by 21.5 points. The game's point total is set at 142.5.

Keep reading to get everything you need to know before wagering on the Michigan State-East Carolina game.

Michigan State vs. East Carolina How to Watch & Odds

• When: Tuesday, November 25, 2025 at 1 p.m. ET
• Where: Suncoast Credit Union Arena in Cypress Lake, Florida
• TV: FS2
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

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Michigan State vs. East Carolina Prediction

• Pick ATS: Michigan State (-21.5)
  
• Pick OU: Over (142.5)
  
• Prediction: Michigan State 86, East Carolina 64

Learn more about the Michigan State Spartans vs. the East Carolina Pirates game on FOX Sports!

Michigan State vs. East Carolina Betting Insights

Betting Line Implied Predictions

• Per the spread and over/under, the implied score for the encounter is Spartans 82, Pirates 60.
• The Spartans have a 98.7% chance to claim victory in this game per the moneyline's implied probability.
• The Pirates hold a 4.6% implied probability to win.

Key Spread Facts

• Michigan State has won two games against the spread this season.
• East Carolina is winless against the spread this year (0-4-0).
• Michigan State has been favored by 21.5 points or more this season three times and failed to cover in all three.

Key Total Facts

• The Spartans and their opponent have combined to score more than 142.5 points two times this season.
• So far this season, three Pirates games have featured over 142.5 points scored.
• These two teams score a combined average of 151 points per game, higher than the total for this matchup by 8.5 points.

Key Moneyline Facts

• Michigan State has won all four games when listed as the moneyline favorite this season.
• East Carolina has lost both games it has played as underdogs this season.
• Michigan State has won all three games it played as a moneyline favorite with odds of -7692 or shorter.
• East Carolina has not entered a game this season with longer moneyline odds than +2075.

Michigan State vs. East Carolina: 2025-26 Stats Comparison

Michigan State 2025-26 Key Players

East Carolina 2025-26 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Big Ten

Michigan State Spartans

East Carolina Pirates