Illinois vs. Missouri Prediction, How to Watch, Odds, Channel - Dec 22

The Missouri Tigers (10-2) hope to build on a nine-game home win streak when they host the No. 18 Illinois Fighting Illini (8-3) on Monday, December 22, 2025 at 8 p.m. ET.

The Fighting Illini are an 8.5-point favorite against the Tigers when the Fighting Illini and the Tigers square off. The game's point total is set at 155.5.

Continue reading to get everything you need to know ahead of wagering on the Illinois-Missouri matchup.

Illinois vs. Missouri How to Watch & Odds

• When: Monday, December 22, 2025 at 8 p.m. ET
• Where: Enterprise Center in St. Louis, Missouri
• TV: FS1
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

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Illinois vs. Missouri Prediction

• Pick ATS: Missouri (+8.5)
  
• Pick OU: Over (155.5)
  
• Prediction: Illinois 83, Missouri 75

Learn more about the Illinois Fighting Illini vs. the Missouri Tigers game on FOX Sports!

Illinois vs. Missouri Betting Insights

Betting Line Implied Predictions

• Based on the spread and over/under, the implied score for the matchup is Fighting Illini 82, Tigers 74.
• The Fighting Illini have a 79.8% chance to claim victory in this matchup per the moneyline's implied probability.
• The Tigers hold a 24.4% implied probability to come out on top.

Key Spread Facts

• Illinois has covered six times in 11 matchups with a spread this season.
• Missouri has covered five times in 12 games with a spread this year.
• Illinois is 3-3 ATS this season when playing as at least 8.5-point favorites.

Key Total Facts

• In eight games this season, the Fighting Illini and their opponent have combined to score more than 155.5 points.
• Tigers games have had over 155.5 points six times this year.
• These teams score 174.6 points per game combined, higher than the over/under for this matchup by 19.1.

Key Moneyline Facts

• Illinois is 7-2 in games when it was favored on the moneyline (winning 77.8%).
• Missouri lost the only game it has played as the underdog this season.
• Illinois has a record of 5-1 when it has played as a moneyline favorite with odds of -394 or shorter (winning 83.3%).
• Missouri has not entered a game this season with longer moneyline odds than +310.

Illinois vs. Missouri: Recent Results

Illinois vs. Missouri: 2025-26 Stats Comparison

Illinois 2025-26 Key Players

Missouri 2025-26 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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