Illinois vs. Missouri Prediction, How to Watch, Odds, Channel - Dec 22

Updated Dec. 22, 2025 8:27 p.m. ET

Data Skrive

The Missouri Tigers (10-2) will host the No. 20 Illinois Fighting Illini (8-3) after winning nine straight home games. The contest begins at 8 p.m. ET on Monday, December 22, 2025.

The Fighting Illini head into their matchup against the Tigers as a 9.5-point favorite. The point total for the game is 154.5.

Keep reading to get the details before placing bets on the Illinois-Missouri game.

Illinois vs. Missouri How to Watch & Odds

When: Monday, December 22, 2025 at 8 p.m. ET
Where: Enterprise Center in St. Louis, Missouri
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Fighting Illini vs Tigers Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Fighting Illini	-9.5	-111	-113	154.5	-110	-110	-476	+365

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Illinois vs. Missouri Prediction

Pick ATS: Missouri (+9.5)
Pick OU: Over (154.5)
Prediction: Illinois 83, Missouri 75

Learn more about the Illinois Fighting Illini vs. the Missouri Tigers game on FOX Sports!

Illinois vs. Missouri Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the matchup is Fighting Illini 82, Tigers 72.
The Fighting Illini have an 82.6% chance to claim victory in this contest per the moneyline's implied probability.
The Tigers sit with a 21.5% implied probability to win.

Key Spread Facts

Illinois has put together a 6-5-0 ATS record so far this year.
Missouri has compiled a 5-7-0 ATS record so far this season.
Illinois has been favored by 9.5 points or more six times this season, and covered the spread in three of those matchups.

Key Total Facts

Eight times so far this season, the Fighting Illini and their opponent have combined for more than 154.5 points.
Tigers games have finished with over 154.5 points scored seven times this season.
The over/under for this game is 154.5 points, 20.1 fewer than the scoring average of the two teams combined.

Key Moneyline Facts

Illinois is 7-2 in games when it was listed as the moneyline favorite (winning 77.8%).
Missouri lost the only game it has played as the underdog this season.
Illinois has gone 5-1 in games it has played as a moneyline favorite with odds of -476 or shorter (winning 83.3%).
Missouri has not entered a game this season with longer moneyline odds than +365.

Illinois vs. Missouri: Recent Results

Fighting Illini vs Tigers Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
12/22/2024	Fighting Illini	-3.5	156	-175	+146	80-77 ILL

Illinois vs. Missouri: 2025-26 Stats Comparison

	Illinois	Missouri
Points Scored Per Game (Rank)	87.8 (35)	86.8 (44)
Points Allowed (Rank)	71.5 (138)	69.8 (100)
Rebounds (Rank)	12.2 (26)	10.5 (112)
3pt Made (Rank)	9.8 (56)	8 (183)
Assists (Rank)	14.4 (186)	15.8 (106)
Turnovers (Rank)	9.5 (28)	12.9 (282)

Illinois 2025-26 Key Players

Fighting Illini Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Kylan Boswell	11	16.1	4.3	3.5	0.6	0	1.5
Andrej Stojakovic	10	15.5	4.1	1.1	0.5	0.7	0.6
Keaton Wagler	11	15.1	4.8	3.3	0.7	0.3	1.9
David Mirkovic	11	13.6	8.8	2.4	0.5	0.3	1.3
Tomislav Ivisic	8	10	4.8	1.4	0.4	0.6	1.4

Missouri 2025-26 Key Players

Tigers Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Mark Mitchell	12	18.2	6.1	3	0.8	0.3	0.3
Jacob Crews	12	14.8	4.8	0.3	0.5	0.2	3.1
Jayden Stone	6	13.3	4.5	2.7	1.2	0.2	1.7
Anthony Robinson II	12	10.8	3.7	3.7	2.2	0.5	1.1
Sebastian Mack	12	8.4	1.5	0.8	1.3	0.1	0.5