2026 NFL Odds Week 2: Lines, Spreads, Results For All 16 Games

Week 2 is in our sights, and it kicked off with that Thursday night win for the Bills over the Lions.

Here are the lines for every Week 2 matchup at bet365 Sportsbook as of Sept. 20. 

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Lions 31, Bills 41

Spread: Bills -4.5 (BUF covers)
O/U: 54.5 (Over hits)

Panthers 34, Falcons 3

Spread: Panthers -2.5 (CAR covers)
O/U: 43.5 (Under hits)

Bengals 20, Texans 6

Spread: Texans -2.5 (CIN covers)
O/U: 45.5 (Under hits)

Browns @ Buccaneers

Spread: Bucs -8.5
Moneyline: Bucs -425, Browns +325
O/U: 41.5

Packers 20, Jets 17 (OT)

Spread: Packers -3.5 (NYJ cover)
O/U: 44.5 (Under hits)

Vikings 9, Bears 3

Spread: Bears -4.5 (MIN covers)
O/U: 47.5 (Under hits)

Saints 24, Ravens 17

Spread: Ravens -8.5 (NO covers)
O/U: 45.5 (Under hits)

Eagles 24, Titans 20

Spread: Eagles -6.5 (TEN covers)
O/U: 39.5 (Over hits)

Steelers 3, Patriots 20

Spread: Patriots -5.5 (NE covers)
O/U: 41.5 (Under hits)

Jaguars @ Broncos

Spread: Broncos -2.5
Moneyline: Broncos -150, Jaguars +125
O/U: 45.5

Raiders @ Chargers

Spread: Chargers -6.5
Moneyline: Chargers -310, Raiders +250
O/U: 43.5

Dolphins @ 49ers

Spread: 49ers -13.5
Moneyline: 49ers -1000, Dolphins +650
O/U: 44.5

Seahawks @ Cardinals 

Spread: Seahawks -3.5
Moneyline: Seahawks -210, Cardinals +175
O/U: 40.5

Commanders @ Cowboys

Spread: Cowboys -4.5
Moneyline: Cowboys -210, Commanders +175
O/U: 50.5

Colts @ Chiefs

Spread: Chiefs -6.5
Moneyline: Chiefs -280, Colts +230
O/U: 46.5

Giants @ Rams

Spread: Rams -6.5
Moneyline: Rams -315, Giants +255
O/U: 47.5