Arizona Cardinals vs. San Francisco 49ers - Live Score - September 27, 2026

Cardinals

0-0

SEP 27, 8:05PM

1-0

49ers

1-0

ODDS

- PTS/G 27.0

- PASS YARDS 205.0

- RUSH YARDS 174.0

- OPP PTS/G 7.0

- OPP PASS YARDS 168.0

- OPP RUSH YARDS 122.0

SCHEDULE

LEAGUE SCORES

RECENT GAMES

ARI			RESULT	ATS	O/U
8/28	@	GB	L38-42	+1.5	O 36.5
8/22	vs	DAL	L13-34	+1.5	O 38.5
8/13	@	LV	W27-14	+3.0	U 41.5
8/6	vs	CAR	L30-33	+1.5	O 34.5

SF			RESULT	ATS	O/U
9/10	@	LAR	W27-7	+3.5	U 47.5
8/27	@	LV	W18-12	+3.5	U 36.5
8/20	@	LAC	W41-17	+1.5	O 38.5
8/13	vs	TEN	L13-19	+6.5	U 40.5

HEAD-TO-HEAD

STARTING QUARTERBACKS

TBD

PASSING YDS -

TDS -

INT -

Brock Purdy #13 · SF

PASSING YDS 205

1st

TDS 3

1st

INT 1

T-4th

FOX FACTS

INSIGHT

For the 2025 regular season, the 49ers had 109.85 passer rating in the red zone, highest in the NFL.

INSIGHT

The 49ers had 20 sacks, the fewest in the NFL for the 2025 regular season.

INSIGHT

The Cardinals' 617 passing targets ranked 1st in the NFL for the 2025 regular season.

PLAYER NEWS

Jeremiyah Love ARI #4 · RB

Love (ankle) is expected to play Sunday against the Chargers, Josh Weinfuss of ESPN.com reports.

Christian McCaffrey SF #23 · RB

McCaffrey rushed 10 times for 68 yards and brought in five of eight targets for 20 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.

Deebo Samuel Sr. SF #19 · WR

Samuel brought in six of seven targets for 48 yards and a touchdown, rushed once for 12 yards and returned two kickoffs for 74 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.