Skenes didn't factor into the decision in Friday's 8-7 loss to the Reds, coughing up five runs on seven hits and four walks over four innings. He struck out seven.
Soto (5-3) allowed one earned run on one hit and two walks while striking out one across two-thirds of an inning to take the loss Thursday against the Reds.
Barco could be used as a bulk reliever behind opening pitcher Yohan Ramirez in Thursday's game in Cincinnati, Danny Demilio of PittsburghBaseballNow.com reports.
Pirates director of sports medicine Todd Tomczyk said Wednesday that Cruz (hand) has been cleared for all baseball activities, Alex Stumpf of MLB.com reports.
Pirates director of sports medicine Todd Tomczyk said Wednesday that Hernandez is expected to be out for 6-to-8 weeks while recovering from a left oblique strain, Danny Demilio of PittsburghBaseballNow.com reports.
Dotel (1-3) was tagged with the loss Tuesday against the Diamondbacks after allowing an unearned run on two hits and a walk across two innings. He didn't record a strikeout.
Chandler didn't factor into the decision Tuesday against the Diamondbacks despite allowing five runs (four earned) on eight hits and a walk across four innings. He struck out three.
Horwitz (hamstring) was diagnosed with a concussion Tuesday after being hit in the helmet with a pitch while on a rehab assignment at Single-A Bradenton, Aiden Stepansky of MLB.com reports.
Pirates general manager Ben Cherington said Sunday that Cruz (hand) has had "good days of late" and could be ready to start up a rehab assignment in early August, Dominic Campbell of SI.com reports.