Valdez (5-7) took the loss against the Cubs on Tuesday, giving up six runs on five hits and two walks while striking out one batter over two-thirds of an inning.
Tigers manager A.J. Hinch said that Montero will start Wednesday's series finale versus the Cubs at Wrigley Field, Jeff Seidel of the Detroit Free Press reports.
Holton picked up the save in Monday's 8-6 extra-inning win over the Cubs. He allowed one unearned run on two hits and no walks with no strikeouts over one inning.
Flaherty did not factor into the decision of Monday's extra-inning win, allowing three runs on four hits and two walks over four innings against the Cubs. He struck out four.
Carpenter has been playing through a bruised heel over the last few games, and he was removed from Monday's game against the Cubs after appearing to be in some discomfort, Evan Woodbery of MLive.com reports.
Jobe (elbow) struck out three and allowed one unearned run on three hits and no walks across three innings Sunday in his rehab start with Double-A Erie.
Mize is dealing with groin tightness and a wrist injury following his early departure from Sunday's 3-2 loss to the Angels, Chris McCosky of The Detroit News reports.
Mize exited Sunday's start against the Angels in fourth inning after being struck in the left hand by a comebacker, Chris McCosky of The Detroit News reports.
Skubal (6-5) earned the win over the Angels on Saturday, allowing five hits and issuing no walks while striking out nine batters over seven scoreless innings.
Melton didn't factor into the decision Friday against the Angels, allowing one run on four hits and four walks while striking out nine over 5.2 innings.
Montero (6-5) earned the win in relief Friday against the Angels after tossing 3.1 scoreless innings, allowing one hit and striking out five without a walk.