The Biggest NFL Upsets in Week 16 - 2025

In Week 16 of the 2025 NFL season, how many underdogs emerged victorious? Below, we provide a complete list of the teams that pulled off an upset last week.

Read more about last week's NFL games on FOX Sports!

NFL Week 16's Biggest Upsets

Steelers 29, Lions 24

• Spread: Lions -7.5
• Total: Over (52)
• Moneyline: Lions -375, Steelers +300

Patriots 28, Ravens 24

• Spread: Ravens -3.5
• Total: Over (48.5)
• Moneyline: Ravens -190, Patriots +155

Jaguars 34, Broncos 20

• Spread: Broncos -3.5
• Total: Over (47)
• Moneyline: Broncos -185, Jaguars +154

Panthers 23, Buccaneers 20

• Spread: Buccaneers -3
• Total: Under (45)
• Moneyline: Buccaneers -155, Panthers +130

Titans 26, Chiefs 9

• Spread: Chiefs -3
• Total: Under (37.5)
• Moneyline: Chiefs -170, Titans +140

Chargers 34, Cowboys 17

• Spread: Cowboys -1.5
• Total: Over (50.5)
• Moneyline: Cowboys -120, Chargers +100

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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