The Biggest NFL Upsets in Week 16 - 2025

You want upsets? We've got upsets. Multiple underdogs took down the favorite in Week 16 of the 2025 NFL season. Keep reading to find a full list of the teams that beat the odds.

Read more about last week's NFL games on FOX Sports!

NFL Week 16's Biggest Upsets

Steelers 29, Lions 24

• Spread: Lions -7.5
• Total: Over (52)
• Moneyline: Lions -375, Steelers +300

Patriots 28, Ravens 24

• Spread: Ravens -3.5
• Total: Over (48.5)
• Moneyline: Ravens -190, Patriots +155

Jaguars 34, Broncos 20

• Spread: Broncos -3.5
• Total: Over (47)
• Moneyline: Broncos -185, Jaguars +154

Panthers 23, Buccaneers 20

• Spread: Buccaneers -3
• Total: Under (45)
• Moneyline: Buccaneers -155, Panthers +130

Titans 26, Chiefs 9

• Spread: Chiefs -3
• Total: Under (37.5)
• Moneyline: Chiefs -170, Titans +140

Chargers 30, Cowboys 23

• Spread: Cowboys -1.5
• Total: Over (50.5)
• Moneyline: Cowboys -120, Chargers +100

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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