The Biggest NFL Upsets in Week 10 - 2025

You want upsets? We've got upsets. Multiple underdogs defeated the favorite in Week 10 of the 2025 NFL season. Continue reading to find a complete list of the teams that defied the odds.

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NFL Week 10's Biggest Upsets

Dolphins 30, Bills 13

• Spread: Bills -8.5
• Total: Under (50)
• Moneyline: Bills -450, Dolphins +350

Saints 17, Panthers 7

• Spread: Panthers -5.5
• Total: Under (38.5)
• Moneyline: Panthers -250, Saints +200

Patriots 28, Buccaneers 23

• Spread: Buccaneers -2.5
• Total: Over (48.5)
• Moneyline: Buccaneers -150, Patriots +125

Jets 27, Browns 20

• Spread: Browns -2
• Total: Over (37.5)
• Moneyline: Browns -130, Jets +110

Eagles 10, Packers 7

• Spread: Packers -1
• Total: Under (45)
• Moneyline: Packers -110, Eagles -110

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.