Texans vs. Titans 2025 Prediction, Odds, Picks - Sep 28

In a battle featuring two teams coming off defeats, the Houston Texans (0-3) will face the Tennessee Titans (0-3). The Texans have dropped three in a row, the Titans three in a row. Houston is a solid favorite (currently -7.5). The expected point total for the matchup is set at 40.5.

Keep up with the 2025 NFL season on FOX Sports.

Texans vs. Titans Odds & Betting Lines

Texans vs. Titans Prediction & Pick

• Pick ATS: Texans (-7.5)
  
• Pick OU: Over (40.5)
  
• Prediction: Texans 30 - Titans 14

How to Watch Houston vs. Tennessee

• Game date: Sunday, September 28, 2025
• Time: 1 p.m. ET
• Venue: NRG Stadium
• Location: Houston, Texas
• TV: CBS
• Live Boxscore: FOX Sports

Texans vs. Titans Recent Matchups

• Over their last five meetings, Houston has put up four wins versus Tennessee.
• Tennessee has been outscored by 35 points in its last five tilts versus Houston.

Houston Betting Info

• Houston is winless against the spread this year.
• Houston games this year have not hit the over yet in three opportunities.
• The Texans have been moneyline favorites one other time this season, a game they lost.
• Looking at this matchup's moneyline, the Texans' implied win probability is 81.5%.

Texans Stats

Houston's Key Players

Offense

• C.J. Stroud has thrown for 599 yards, two touchdowns and three interceptions this year. He averages 199.7 yards per game and 6.7 per attempt, while completing 64.0% of his attempts.
• He has also rushed for 81 yards (second on the Texans) without scoring a touchdown on the ground, while averaging 27.0 rushing yards per game.
• Nico Collins' 181 receiving yards this season have come from 25 targets and 14 receptions. He's averaging 60.3 receiving yards and 4.7 catches per game, with two receiving touchdowns (seventh in the NFL).
• Nick Chubb has 141 rushing yards with one touchdown (47.0 yards per game across three games).
• Chubb also has five catches, 31 yards and zero TDs in the passing game.
• Dalton Schultz has 96 receiving yards without a touchdown with 11 catches on 15 targets. He is averaging 3.7 receptions and 32.0 yards per game.

Defense

• On the defensive side for the Texans, Will Anderson Jr. has powered the unit with 12 tackles, 5.0 TFL, and three sacks in 2025.
• Azeez Al-Shaair has 25 tackles this season. His tackle total leads the Texans.
• Henry To'oTo'o has recorded 21 tackles, 2.0 TFL, and one sack this year. He's second on the Texans in tackles.
• This season, Danielle Hunter has eight tackles, 2.0 TFL, and two sacks.

Tennessee Betting Info

• Tennessee has covered the spread one time over three games with a set spread.
• The Titans have been underdogs by 7.5 points or more once this year and covered the spread.
• Games involving Tennessee have hit the over twice this season.
• This season, the Titans have been listed as the underdog in three games and failed to win any of those contests.
• The Titans have a 22.7% chance to win this game based on the implied probability of the moneyline.

Titans Stats

Tennessee's Key Players

Offense

• Tony Pollard averages 65.7 rushing yards per game this year (197 total yards), while scoring one rushing touchdown.
• On top of his impact in the run game, Pollard has caught three pass (on six targets) for 43 yards (sixth on the Titans). He's averaging 14.3 yards per game.
• Cameron Ward has 506 passing yards, two touchdowns and one interception. His completion percentage is 54.5% and he averages 168.7 yards per game and 5.1 per attempt.
• Elic Ayomanor has totaled 107 receiving yards and two touchdowns (seventh in the NFL) on 10 receptions, while being targeted 18 times this season.
• Chigoziem Okonkwo has 120 receiving yards from 12 receptions after getting 16 targets.

Defense

• Amani Hooker has 1.0 sack (first on the Titans) to go with 1.0 TFL and 18 tackles through three games in 2025.
• Cody Barton has one interception on top of 20 tackles, 1.0 TFL, and one pass defended. He's eighth in the league in interceptions.
• Jeffery Simmons has 1.0 sack (first on the Titans) in addition to his 1.0 TFL and nine tackles.
• Xavier Woods has registered 14 tackles and one interception over three games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Houston Texans

Tennessee Titans