Rams vs. Cardinals 2025 Prediction, Odds, Picks - Jan 4

The Arizona Cardinals (3-13) will be attempting to end an eight-game losing streak against the Los Angeles Rams (11-5). The Rams are solid favorites, expected to win by at least a touchdown (currently -8.5). The expected point total for the matchup is set at 46.5.

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Rams vs. Cardinals Odds & Betting Lines

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Rams vs. Cardinals Prediction & Pick

• Pick ATS: Rams (-8.5)
  
• Pick OU: Over (46.5)
  
• Prediction: Rams 38 - Cardinals 12

How to Watch Los Angeles vs. Arizona

• Game date: Sunday, January 4, 2026
• Time: 4:25 p.m. ET
• Venue: SoFi Stadium
• Location: Inglewood, California
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Rams vs. Cardinals Recent Matchups

• Over their last five meetings, Los Angeles has totaled four wins against Arizona.
• Over their last five head-to-head contests, Los Angeles has racked up 131 points, while Arizona has compiled 90.

Los Angeles Betting Info

• Los Angeles has 11 wins in 16 games versus the spread this season.
• The Rams have been favored by 8.5 points or more four times this season, and covered the spread in two of those games.
• Los Angeles has combined with its opponent to hit the over in 56.2% of its contests this year (nine times over 16 games with a set point total).
• When playing as moneyline favorites, the Rams have won 78.6% of the time (11-3).
• Looking at this matchup's moneyline, the Rams' implied win probability is 81.0%.

Rams Stats

Los Angeles' Key Players

Offense

• Matthew Stafford ranks second in the NFL with 4,448 passing yards in 16 games this year, averaging 278.0 per game with a 65.2% completion percentage and 42 touchdowns (first in the NFL) against eight interceptions.
• Puka Nacua has caught 119 passes (first in the NFL) on 155 targets for 1,639 total yards (second in the NFL) and nine touchdowns. He is averaging 7.9 catches and 109.3 yards per game in 15 games.
• Through 16 games, Kyren Williams has amassed 1,192 yards on the ground (seventh in the NFL), averaging 74.5 yards per game and scoring 10 touchdowns.
• Williams has recorded 33 receptions, 260 yards and three TDs through the air.
• Davante Adams has 60 receptions for 789 yards and 14 touchdowns. He's been targeted 114 times in the passing game, and averages 4.3 receptions and 56.4 yards in 14 games played.

Defense

• On defense, Nathan Landman has 2.5 sacks (fourth on the Rams) to go with 8.0 TFL, 129 tackles, and one interception in 2025.
• Byron Young has 80 tackles, 11.0 TFL, and 11 sacks.
• Kamren Curl has recorded 117 tackles, 2.0 TFL, two sacks, and two interceptions this year.
• So far this season, Jared Verse has 56 tackles, 10.0 TFL, and 6.5 sacks.

Arizona Betting Info

• Arizona has gone 6-10-0 against the spread this year.
• The Cardinals have been underdogs by 8.5 points or more three times this year and covered the spread once.
• Arizona games have gone over the total nine times this season.
• The Cardinals have entered the game as underdogs 13 times this season and won once.
• The implied probability of a win by the Cardinals based on the moneyline is 23.3%.

Cardinals Stats

Arizona's Key Players

Offense

• In 13 games played this year, Jacoby Brissett has totaled 3,123 passing yards, with 21 touchdowns against seven interceptions and completing 64.5% of his attempts.
• He's added 149 yards on the ground (sixth on the Cardinals), while scoring one rushing touchdown. He's averaging 11.5 yards per game and 4.3 per attempt.
• Trey McBride has 119 catches (first in the NFL) for 1,174 yards (sixth in the NFL) and 11 receiving touchdowns (second in the NFL). He has been targeted 161 times and averages 7.4 receptions per game in 16 games played.
• So far this season, Michael Wilson has caught 73 passes for 907 receiving yards with six touchdowns through the air. He has been targeted 118 total times and is averaging 4.6 receptions per game through 16 games played.
• Marvin Harrison Jr. has been targeted 73 times, resulting in 41 catches for 608 yards .

Defense

• Josh Sweat has 28 tackles, 12.0 TFL, 11 sacks, and two passes defended in 2025.
• Akeem Davis-Gaither has one interception on top of 94 tackles, 2.0 TFL, and five passes defended.
• In the 2025 campaign, Budda Baker has 111 tackles, 2.0 TFL, 0.5 sacks, and one interception through 15 games.
• Jalen Thompson has put up 1.0 sack to go with 2.0 TFL and 85 tackles through 14 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Rams

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