Lions vs. Steelers 2025 Prediction, Odds, Picks - Dec 21

The Detroit Lions (8-6) are considered favorites (-6.5) according to the oddsmakers ahead of their game against the Pittsburgh Steelers (8-6) on December 21, 2025, starting at 4:25 p.m. ET, airing on CBS. The expected point total for the matchup is set at 52.5.

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Lions vs. Steelers Odds & Betting Lines

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Lions vs. Steelers Prediction & Pick

• Pick ATS: Lions (-6.5)
  
• Pick OU: Under (52.5)
  
• Prediction: Lions 29 - Steelers 22

How to Watch Detroit vs. Pittsburgh

• Game date: Sunday, December 21, 2025
• Time: 4:25 p.m. ET
• Venue: Ford Field
• Location: Detroit, Michigan
• TV: CBS
• Live Boxscore: FOX Sports

Lions vs. Steelers Recent Matchups

• In their past two matchups, Pittsburgh holds a split 1-1 record against Detroit.
• In their last two head-to-head matchups, Pittsburgh has scored 36 points versus Detroit, while allowing only 31 points.

Detroit Betting Info

• Detroit has seven wins in 14 games versus the spread this season.
• The Lions have covered the spread three times this season (3-2 ATS) when playing as at least 6.5-point favorites.
• Detroit contests this year have gone over the point total 64.3% of the time (nine times in 14 games with a set point total).
• When playing as moneyline favorites, the Lions are 7-2, picking up a win 77.8% of the time.
• The implied probability for this matchup, considering the moneyline, gives the Lions a 76.5% chance to win.

Lions Stats

Detroit's Key Players

Offense

• On the ground, Jahmyr Gibbs averages 5.5 yards per attempt (second in the NFL) and 78.6 yards per game for 1,100 total rushing yards (seventh in the NFL). He has scored 13 rushing touchdowns this season.
• Gibbs has 73 targets, 62 catches, 494 receiving yards and three TDs in the passing game.
• Jared Goff has 3,672 passing yards (fourth in the NFL), 29 touchdowns (second in the NFL) and five interceptions this year. He has completed 69.3% of his attempts, averaging 262.3 yards per game and 8.1 per attempt.
• In the passing attack, Amon-Ra St. Brown, has racked up 1,140 receiving yards (fifth in the NFL) and 11 touchdowns (second in the NFL) after pulling down 94 balls (fifth in the NFL) on 135 targets. Per game, he's averaging 81.4 yards and 6.7 receptions over 14 games.
• Jameson Williams has 52 catches for 936 yards (10th in the NFL) and seven touchdowns. He's been targeted 82 times in the passing game, and averages 3.7 receptions and 66.9 yards in 14 games played.

Defense

• Over on defense, Jack Campbell has 136 tackles, 9.0 TFL, and five sacks in 2025. His tackle total leads the Lions and is fifth in the NFL.
• Aidan Hutchinson has 39 tackles, 9.0 TFL, 9.5 sacks, and one interception this season.
• Alex Anzalone has collected 84 tackles, 3.0 TFL, 1.5 sacks, and one interception this year. He's second on the Lions in tackles.
• Derrick Barnes has 4.0 sacks (fourth on the Lions) as well as 6.0 TFL, 63 tackles, and one interception on the season.

Pittsburgh Betting Info

• Pittsburgh has covered the spread in a matchup seven times this season (7-7-0).
• Games involving Pittsburgh have hit the over on eight occasions this year.
• This season, the Steelers have won three out of the seven games in which they've been the underdog.
• The Steelers have a 27.8% chance to win this game based on the implied probability of the moneyline.

Steelers Stats

Pittsburgh's Key Players

Offense

• Aaron Rodgers is averaging 7.0 passing yards per attempt (17th in the NFL) and 199.5 yards per game this year, completing 66.8% of his passes on the way to 2,594 total yards, 22 touchdowns and seven interceptions through 13 games.
• He's added 26 yards on the ground (fifth on the Steelers), while scoring one rushing touchdown. He's averaging 2.0 yards per game and 1.5 per attempt.
• Jaylen Warren has 685 rushing yards (leading the Steelers) and four rushing touchdowns, while averaging 52.7 yards per game and 4.0 per carry (32nd in the NFL).
• Warren has also collected 292 receiving yards (22.5 per game) on 33 catches (2.5 per game). He's been targeted 38 times and has caught two touchdown passes.
• D.K. Metcalf has recorded 808 receiving yards and six touchdowns on 55 receptions, while being targeted 90 times on the season.
• Kenneth Gainwell has 451 rushing yards (second on the Steelers) and four rushing touchdowns, while averaging 32.2 yards per game and 4.8 per carry (11th in the NFL).
• Gainwell has added 57 catches (4.1 per game) for 332 yards (23.7 per game) and two receiving touchdowns. He has been on the receiving end of 65 targets.

Defense

• Payton Wilson has intercepted one pass in addition to 100 tackles, 6.0 TFL, two sacks, and two passes defended in 2025.
• T.J. Watt has one interception on top of 53 tackles, 10.0 TFL, seven sacks, and seven passes defended.
• Patrick Queen has 106 tackles, 7.0 TFL, and one sack in the 2025 campaign. He leads the Steelers in tackles.
• Nick Herbig has 6.5 sacks (second on the Steelers) to go with 12.0 TFL, 29 tackles, and one interception over 13 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Lions

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