Lions vs. Steelers 2025 Prediction, Odds, Picks - Dec 21

The Detroit Lions (8-6) are considered favorites (-7.5) according to the oddsmakers ahead of their game against the Pittsburgh Steelers (8-6) on December 21, 2025, starting at 4:25 p.m. ET, airing on CBS. The expected point total for the matchup is set at 52.5.

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Lions vs. Steelers Odds & Betting Lines

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Lions vs. Steelers Prediction & Pick

• Pick ATS: Steelers (+7.5)
  
• Pick OU: Under (52.5)
  
• Prediction: Lions 29 - Steelers 22

How to Watch Detroit vs. Pittsburgh

• Game date: Sunday, December 21, 2025
• Time: 4:25 p.m. ET
• Venue: Ford Field
• Location: Detroit, Michigan
• TV: CBS
• Live Boxscore: FOX Sports

Lions vs. Steelers Recent Matchups

• The last two times Pittsburgh and Detroit have played, the two teams share the same 1-1 record.
• Detroit has been outpaced by 5 points in its last two tilts against Pittsburgh.

Detroit Betting Info

• Detroit has played 14 games, posting seven wins against the spread.
• When playing as at least 7.5-point favorites this season, the Lions have an ATS record of 3-2.
• Detroit contests this year have gone over the point total 64.3% of the time (nine times in 14 games with a set point total).
• When playing as moneyline favorites, the Lions are 7-2, picking up a victory 77.8% of the time.
• Looking at this matchup's moneyline, the Lions' implied win probability is 80.4%.

Lions Stats

Detroit's Key Players

Offense

• Jahmyr Gibbs' rushing stat line this season includes 1,100 yards (seventh in the NFL) and 13 TDs. He's averaging 78.6 yards per game and 5.5 per attempt (second in the NFL).
• He's hauled in 62 passes (on 73 targets) for 494 receiving yards with three touchdowns. He's averaging 35.3 receving yards and 4.4 catches per game.
• Jared Goff has 3,672 passing yards (fourth in the NFL), 29 touchdowns (second in the NFL) and five interceptions this year. He has completed 69.3% of his attempts, averaging 262.3 yards per game and 8.1 per attempt.
• In 14 games played, Amon-Ra St. Brown is averaging 81.4 yards and 6.7 receptions per game to total 1,140 receiving yards (fifth in the NFL) and 94 catches (fifth in the NFL). He's been targeted 135 times, and has 11 receiving touchdowns (second in the NFL).
• Jameson Williams averages 3.7 receptions and 66.9 yards per game, and has 936 total receiving yards (10th in the NFL) and 52 catches. He's gotten 82 total targets, and has caught seven touchdown passes (ninth in the NFL).

Defense

• Over on defense, Jack Campbell has 136 tackles, 9.0 TFL, and five sacks in 2025. His tackle total leads the Lions and is fifth in the NFL.
• Aidan Hutchinson has intercepted one pass and has added 39 tackles, 9.0 TFL, 9.5 sacks, and three passes defended.
• Alex Anzalone has collected 84 tackles, 3.0 TFL, 1.5 sacks, and one interception this year.
• So far this season, Derrick Barnes has 63 tackles, 6.0 TFL, four sacks, and one interception. He's fourth on the Lions in tackles.

Pittsburgh Betting Info

• Pittsburgh is 7-7-0 against the spread this year.
• This season, Pittsburgh games have hit the over eight times.
• This season, the Steelers have been the underdog seven times and won three of those games.
• Oddsmakers have implied with the moneyline set for this matchup that the Steelers have a 23.8% chance to win.

Steelers Stats

Pittsburgh's Key Players

Offense

• In 13 games played this year, Aaron Rodgers has amassed 2,594 passing yards, while throwing 22 touchdowns against seven interceptions and completing 66.8% of his passes.
• On the ground, Rodgers has added one rushing touchdown and 26 rushing yards (fifth on the Steelers).
• Jaylen Warren has scored four rushing touchdowns, while totaling 685 rushing yards (4.0 per attempt and 52.7 per game).
• Warren also has 33 catches for 292 yards (sixth on the Steelers), with two receiving touchdowns. He has been targeted 38 times and averages 22.5 yards per game.
• In 14 games played this season, D.K. Metcalf has 55 catches (3.9 receptions per game on 6.4 targets per game) for 808 yards and six receiving touchdowns.
• Kenneth Gainwell has 451 rushing yards (second on the Steelers) and four rushing touchdowns, while averaging 32.2 yards per game and 4.8 per attempt (11th in the NFL).
• Gainwell also has 332 receiving yards (23.7 per game) on 57 catches (4.1 per game). He has been targeted 65 times with two touchdown receptions.

Defense

• Payton Wilson has 2.0 sacks to go with 6.0 TFL, 100 tackles, and one interception over 14 games in 2025.
• T.J. Watt has one interception on top of 53 tackles, 10.0 TFL, seven sacks, and seven passes defended.
• Patrick Queen has 106 tackles, 7.0 TFL, one sack, and four passes defended in the 2025 campaign.
• Nick Herbig has intercepted one pass in addition to 29 tackles, 12.0 TFL, 6.5 sacks, and two passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Lions

Pittsburgh Steelers