Lions vs. Browns 2025 Prediction, Odds, Picks - Sep 28

The Detroit Lions (2-1) are considered favorites (-10) according to the oddsmakers ahead of their game versus the Cleveland Browns (1-2) on September 28, 2025, starting at 1 p.m. ET, airing on FOX. The total for this one is set at 44.5 points.

Keep up with the 2025 NFL season on FOX Sports.

Lions vs. Browns Odds & Betting Lines

Lions vs. Browns Prediction & Pick

• Pick ATS: Lions (-10)
  
• Pick OU: Over (44.5)
  
• Prediction: Lions 39 - Browns 9

How to Watch Detroit vs. Cleveland

• Game date: Sunday, September 28, 2025
• Time: 1 p.m. ET
• Venue: Ford Field
• Location: Detroit, Michigan
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Lions vs. Browns Recent Matchups

• In their past two matchups, Cleveland has a split 1-1 record against Detroit.
• Cleveland has been outpaced by 11 points in its last two tilts versus Detroit.

Detroit Betting Info

• So far this season Detroit has two victories against the spread.
• Detroit games this year have gone over the total in two out of three opportunities (66.7%).
• The Lions have been moneyline favorites a single other time this season, a game they won.
• The Lions have an implied win probability, based on the moneyline, of 84.6%.

Lions Stats

Detroit's Key Players

Offense

• Jared Goff ranks eighth in the NFL with 761 passing yards in three games this year, averaging 253.7 per game with a 77.9% completion percentage and seven touchdowns (second in the NFL) against one interception.
• Amon-Ra St. Brown's 237 receiving yards this season (seventh in the NFL) have come from 25 targets and 20 receptions (ninth in the NFL). He's averaging 79.0 receiving yards and 6.7 catches per game, with four receiving touchdowns (first in the NFL).
• David Montgomery's output on the ground this season includes 233 yards (seventh in the NFL) and three TDs. He is averaging 77.7 yards per game and 6.9 per attempt (first in the NFL).
• Montgomery has totaled six receptions on six targets for 35 yards, though he has yet to score a touchdown in the passing game.
• In the running game, Jahmyr Gibbs averages 4.2 yards per attempt (17th in the NFL) and 60.0 yards per game for 180 total rushing yards. He has scored three rushing touchdowns this season.
• He has added 18 catches (on 19 targets) for 73 receiving yards with zero touchdowns. He's averaging 24.3 receiving yards and 6.0 receptions per game.

Defense

• On defense for the Lions, Jack Campbell has powered the unit with 25 tackles, 1.0 TFL, and one sack in 2025.
• Brian Branch has 1.0 sack (third on the Lions) to go with 3.0 TFL and 17 tackles.
• Al-Quadin Muhammad has totaled seven tackles, 3.0 TFL, and 3.5 sacks this year.
• So far this season, Derrick Barnes has 18 tackles, 1.0 TFL, and one sack.

Cleveland Betting Info

• Cleveland has covered the spread two times this season (2-1-0).
• The Browns have yet to cover the spread this year when underdogs by 10 points or more.
• Cleveland games have gone over the total once this year.
• The Browns have won one of the three games they've played as underdogs this season.
• The implied probability of a win by the Browns based on the moneyline is 19.6%.

Browns Stats

Cleveland's Key Players

Offense

• Joe Flacco is averaging 5.0 passing yards per attempt (31st in the NFL) and 210.3 yards per game this year, completing 61.1% of his passes on the way to 631 total yards, two touchdowns and four interceptions through three games.
• Quinshon Judkins averages 77.5 rushing yards per game through two games (155 total yards), while scoring one rushing touchdown.
• Through three games played this season, Cedric Tillman has 10 catches (3.3 receptions per game on six targets per game) for 100 yards and two receiving touchdowns (seventh in the NFL).
• Dylan Sampson is scoreless on the ground, but has rushed for 37 total yards (2.2 per carry and 12.3 per game).
• Sampson also has 77 receiving yards (25.7 per game) on 11 catches (3.7 per game). He has been targeted 11 times with one touchdown reception.

Defense

• So far in 2025, Myles Garrett has amassed 4.0 sacks to go with 7.0 TFL and 16 tackles through three games. He ranks second in the NFL in sacks.
• Devin Bush Jr. has registered 1.0 sack in addition to his 2.0 TFL and 21 tackles over three games.
• Carson Schwesinger has 21 tackles, 2.0 TFL, and one sack during the 2025 campaign.
• Grant Delpit's stat sheet includes one interception (eighth in the NFL) as well as 17 tackles, 1.0 TFL, and two passes defended in three games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Lions

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