Jaguars vs. Colts 2025 Prediction, Odds, Picks - Dec 28

The Indianapolis Colts (8-7) will be trying to snap a five-game losing run against the Jacksonville Jaguars (11-4). The Jaguars are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). The over/under for this one is set at 48.5 points.

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Jaguars vs. Colts Odds & Betting Lines

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Jaguars vs. Colts Prediction & Pick

• Pick ATS: Colts (+4.5)
  
• Pick OU: Over (48.5)
  
• Prediction: Jaguars 27 - Colts 23

How to Watch Jacksonville vs. Indianapolis

• Game date: Sunday, December 28, 2025
• Time: 1 p.m. ET
• Venue: Lucas Oil Stadium
• Location: Indianapolis, Indiana
• TV: Watch on FOX
• Streaming: FOX One (Limited time offer: 50% off the first two months)

Jaguars vs. Colts Recent Matchups

• Jacksonville holds a 4-1 record against Indianapolis in their last five matchups.
• Over their last five head-to-head contests, Jacksonville has scored 164 points, while Indianapolis has posted 120.

Jacksonville Betting Info

• Jacksonville has 10 wins in 15 games versus the spread this year.
• The Jaguars have covered the spread three times this season (3-0 ATS) when playing as at least 4.5-point favorites.
• Jacksonville games in 2025 have gone over the point total nine times in 15 opportunities (60%).
• When playing as the moneyline favorite, the Jaguars have won 85.7% of the time (6-1).
• The Jaguars have a 69.2% chance to win this contest, based on the implied probability of the moneyline.

Jaguars Stats

Jacksonville's Key Players

Offense

• Trevor Lawrence ranks ninth in the NFL with 3,489 passing yards in 15 games this year, averaging 232.6 per game with a 60% completion percentage and 26 touchdowns (fourth in the NFL) against 11 interceptions.
• He has tacked on 322 rushing yards (21.5 per game) and seven touchdowns on the ground.
• Travis Etienne averages 4.4 yards per carry (23rd in the NFL) and 66.6 yards per game, and has 999 total rushing yards. He has recorded seven rushing TDs this season.
• He has hauled in 33 passes (on 48 targets) for 270 receiving yards with six touchdowns. He's averaging 18 receiving yards and 2.2 catches per game.
• Parker Washington has four touchdown catches this season, and has 45 receptions for 645 yards on 76 targets, while averaging 3.2 catches and 46.1 yards per game.
• Jakobi Meyers has 64 catches for 752 yards and three touchdowns. He's been targeted 95 times in the passing game, and averages 4.6 receptions and 53.7 yards in 14 games played.

Defense

• On the defensive side, Foyesade Oluokun has one sack to go with five TFL, 122 tackles, and one interception in 2025.
• Devin Lloyd has 1.5 sacks in addition to his five TFL, 65 tackles, and five interceptions.
• Josh Hines-Allen has put up 41 tackles, 11 TFL, and seven sacks this year.
• This season, Andrew Wingard has 79 tackles, two TFL, and one interception.

Indianapolis Betting Info

• Indianapolis has compiled an 8-7-0 record against the spread this season.
• The Colts have been underdogs by 4.5 points or more three times this year and have covered the spread twice.
• This year, eight Indianapolis games have gone over the point total.
• This season, the Colts have won two out of the six games in which they've been the underdog.
• The implied probability of a win by the Colts based on the moneyline is 35.1%.

Colts Stats

Indianapolis' Key Players

Offense

• Jonathan Taylor has rushed for 17 touchdowns this year, and has 1,489 total rushing yards (99.3 per game and 5.2 per carry).
• Taylor has also been a part of the passing game with 351 yards (23.4 per game) on 41 receptions (2.7 per game), while being targeted 47 times. He has two receiving touchdowns.
• Michael Pittman Jr. has 757 receiving yards and seven touchdowns on 76 receptions, while being targeted 104 times.
• This season, Alec Pierce has caught 43 passes for 871 receiving yards with four touchdowns through the air. He has been targeted 72 total times and is averaging 3.3 receptions per game through 13 games played.
• Tyler Warren has 748 receiving yards and four touchdowns from 66 receptions after receiving 99 targets.

Defense

• So far in 2025, Germaine Pratt has put up six TFL and 114 tackles over 14 games.
• Nick Cross' stats include one interception as well as 101 tackles, four TFL, 2.5 sacks, and five passes defended.
• In the 2025 campaign, Zaire Franklin has 108 tackles, five TFL, and two sacks in 15 games.
• Laiatu Latu has intercepted three passes and also has 41 tackles, 11 TFL, 7.5 sacks, and four passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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