Jaguars vs. Colts 2025 Prediction, Odds, Picks - Dec 28

Having lost five straight, the Indianapolis Colts (8-7) will face the Jacksonville Jaguars (11-4). The Jaguars are the favorites, expected to win by at least a field goal but less than a touchdown (currently -6). The expected point total for the matchup is set at 48.5.

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Jaguars vs. Colts Odds & Betting Lines

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Jaguars vs. Colts Prediction & Pick

• Pick ATS: Colts (+6)
  
• Pick OU: Over (48.5)
  
• Prediction: Jaguars 27 - Colts 23

How to Watch Jacksonville vs. Indianapolis

• Game date: Sunday, December 28, 2025
• Time: 1 p.m. ET
• Venue: Lucas Oil Stadium
• Location: Indianapolis, Indiana
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Jaguars vs. Colts Recent Matchups

• In their last five head-to-head bouts, Jacksonville has won against Indianapolis four times.
• Indianapolis has been outscored by 44 points in its last five tilts against Jacksonville.

Jacksonville Betting Info

• Jacksonville has played 15 games, posting 10 wins against the spread.
• The Jaguars have won each of their two games this season when playing as at least 6-point favorites.
• Jacksonville games this year have hit the over on nine of 15 set point totals (60%).
• When playing as the moneyline favorite, the Jaguars are 6-1, earning a win 85.7% of the time.
• The Jaguars have an implied win probability, based on the moneyline, of 71.4%.

Jaguars Stats

Jacksonville's Key Players

Offense

• Trevor Lawrence has thrown for 3,489 yards (ninth in the NFL), 26 touchdowns (fourth in the NFL) and 11 interceptions this year. He is averaging 232.6 yards per game and 7.1 per attempt, while completing 60.0% of his passes.
• He has added 322 rushing yards (21.5 per game) and seven touchdowns on the ground.
• Travis Etienne has collected 999 rushing yards with seven touchdowns (66.6 yards per game across 15 games). His 4.4 yards per attempt rank 24th in the NFL.
• Etienne has 33 receptions on 48 targets for 270 yards. He has six receiving TDs.
• In the passing attack, Parker Washington, has totaled 645 receiving yards and four touchdowns after hauling in 45 balls on 76 targets. Per game, he's averaging 46.1 yards and 3.2 receptions through 14 games.
• Jakobi Meyers averages 4.6 receptions and 53.7 yards per game, and has 752 total receiving yards and 64 catches. He's gotten 95 total targets, and has caught three touchdown passes.

Defense

• Over on the defensive side, Foyesade Oluokun has one interception to go with 122 tackles, 5.0 TFL, one sack, and 10 passes defended in 2025.
• Devin Lloyd has 65 tackles, 5.0 TFL, 1.5 sacks, and five interceptions this season.
• Josh Hines-Allen has recorded 41 tackles, 11.0 TFL, and seven sacks this year.
• This season, Andrew Wingard has 79 tackles, 2.0 TFL, and one interception. He's second on the Jaguars in tackles.

Indianapolis Betting Info

• Indianapolis has put together a record of 8-7-0 against the spread this season.
• This season, the Colts won ATS in their only game as an underdog of 6 points or more.
• This season, Indianapolis games have hit the over eight times.
• This season, the Colts have won two out of the six games in which they've been the underdog.
• The implied probability of a win by the Colts based on the moneyline is 32.8%.

Colts Stats

Indianapolis' Key Players

Offense

• Jonathan Taylor has rushed for 17 touchdowns this year, and has racked up 1,489 total rushing yards (99.3 per game and 5.2 per carry).
• Taylor has also been a piece of the passing game with 351 yards (23.4 per game) on 41 receptions (2.7 per game), while being targeted 47 times. He has two receiving touchdowns.
• Michael Pittman Jr. has 757 receiving yards and seven touchdowns on 76 receptions, while being targeted 104 times.
• This season, Alec Pierce has caught 43 passes for 871 receiving yards with four touchdowns through the air. He has been targeted 72 total times and is averaging 3.3 receptions per game through 13 games played.
• Tyler Warren has been targeted 99 times, resulting in 66 catches for 748 yards .

Defense

• In 2025, Germaine Pratt has put up 6.0 TFL and 114 tackles over 14 games.
• Nick Cross has one interception on top of 101 tackles, 4.0 TFL, 2.5 sacks, and five passes defended.
• Zaire Franklin has 108 tackles, 5.0 TFL, and two sacks in the 2025 season. He is second on the Colts in tackles.
• Laiatu Latu has intercepted three passes to go with 41 tackles, 11.0 TFL, 7.5 sacks, and four passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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