Commanders vs. Raiders 2025 Prediction, Odds, Picks - Sep 21

The Washington Commanders (1-1) are favored by 2.5 points versus the Las Vegas Raiders (1-1) on September 21, 2025, starting at 1 p.m. ET, airing on FOX. The game has an over/under of 43.5 points.

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Commanders vs. Raiders Odds & Betting Lines

Commanders vs. Raiders Prediction & Pick

• Pick ATS: Commanders (-2.5)
  
• Pick OU: Over (43.5)
  
• Prediction: Commanders 32 - Raiders 16

How to Watch Washington vs. Las Vegas

• Game date: Sunday, September 21, 2025
• Time: 1 p.m. ET
• Venue: Northwest Stadium
• Location: Landover, Maryland
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Commanders vs. Raiders Recent Matchups

• Washington has a 2-0 record against Las Vegas in their last two matchups.
• In their last two head-to-head matchups, Washington has tallied 44 points against Las Vegas, while allowing only 25 points.

Washington Betting Info

• This year, Washington has one win against the spread.
• The Commanders have been favored by 2.5 points or more once this season, and covered the spread.
• Washington games this year have not hit the over on any of two set point totals.
• The Commanders have been moneyline favorites a single other time this season, a game they won.
• The implied probability in this matchup, considering the moneyline, gives the Commanders a 60.8% chance to win.

Commanders Stats

Washington's Key Players

Offense

• Jayden Daniels has thrown for 433 yards, three touchdowns and zero interceptions this year. He averages 216.5 yards per game and 6.0 per attempt, while completing 59.7% of his attempts.
• He has also rushed for 85 yards (second on the Commanders) without scoring a touchdown on the ground, while averaging 42.5 rushing yards per game.
• Deebo Samuel has caught 14 passes (ninth in the NFL) on 18 targets for 121 total yards and one touchdown. He is averaging 7.0 catches and 60.5 yards per game in two games.
• Through two games played, Zach Ertz is averaging 45.0 yards and 4.5 receptions per game on the way to 90 receiving yards and nine catches. He's been targeted 13 times, and has two receiving touchdowns (fifth in the NFL).
• Jacory Croskey-Merritt has run for 99 yards, averaging 49.5 yards per game and scoring one touchdown.

Defense

• On defense, Dorance Armstrong Jr. has 10 tackles, 2.0 TFL, and two sacks in 2025.
• Bobby Wagner has 21 tackles and 1.0 TFL this season. He leads the Commanders in tackles.
• Quan Martin has recorded 12 tackles this year.
• Da'Ron Payne has six tackles, 1.0 TFL, one sack, and two passes defended.

Las Vegas Betting Info

• Las Vegas has covered the spread once in two games with a set spread.
• The Raiders have been underdogs by 2.5 points or more two times this season and covered the spread once.
• Games involving Las Vegas have yet to hit the over once this season.
• The Raiders have split the two games they've played as underdogs this season.
• The implied probability of a win by the Raiders based on the moneyline is 43.5%.

Raiders Stats

Las Vegas' Key Players

Offense

• Geno Smith is averaging 7.0 passing yards per attempt (19th in the NFL) and 271.0 yards per game this year, completing 62.3% of his passes on the way to 542 total yards (ninth in the NFL), one touchdown and four interceptions through two games.
• On the ground, Smith has added 30 rushing yards (second on the Raiders).
• Jakobi Meyers has 14 catches (ninth in the NFL) for 165 yards (10th in the NFL) without a receiving touchdown. He has been targeted 22 times and averages 7.0 receptions per game in two games played.
• This season in two games, Ashton Jeanty has racked up 81 rushing yards (leading the Raiders) and scored one rushing touchdown. He averages 40.5 yards per game and 2.7 per carry (44th in the NFL).
• Brock Bowers has 10 catches for 141 yards without a receiving touchdown. He averages 5.0 yards per game through two games and has been targeted 16 times.

Defense

• Devin White has 19 tackles and 2.0 TFL in 2025.
• Jonah Laulu's stats include six tackles, 3.0 TFL, and three sacks.
• Isaiah Pola-Mao has 1.0 TFL, 12 tackles, and one interception.
• Kyu Blu Kelly has totaled 1.0 TFL and 11 tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Washington Commanders

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