Colts vs. 49ers Injury Report – Week 16, 2025

The Indianapolis Colts (8-6) have 11 players on their injury report as they ready to square off against the San Francisco 49ers (10-4) on Monday, Dec. 22 at Lucas Oil Stadium, with kickoff scheduled for 8:15 p.m. ET. The 49ers' (10-4) injury report currently includes zero players.

Learn more about the San Francisco 49ers vs. the Indianapolis Colts on FOX Sports!

49ers vs. Colts Game Info

• When: Monday, December 22, 2025 at 8:15 p.m. ET
• Where: Lucas Oil Stadium in Indianapolis, Indiana
• TV info: ESPN
• Spread Favorite: 49ers (-5.5)
• Moneyline: 49ers (-270), Colts (+220)
• Total: 46.5 points
• Streaming: FOX One + ESPN Bundle

Colts Injuries

Anthony Richardson | QB

• Injury: Eye
• Practice Status: Limited Participation in Practice

Bernhard Raimann | OT

• Injury: Elbow
• Practice Status: Did Not Participate In Practice
• 2025 Season Stats: 7 Games Played

Germaine Pratt | LB

• Injury: Personal
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 0.0 Sacks | 6.0 Tackles for Loss | 108 Tackles | 0 Interceptions | 7 Passes Defended

Alec Pierce | WR

• Injury: Achilles
• Practice Status: Limited Participation in Practice
• 2025 Receiving Stats: 68 Targets | 39 Receptions | 785 Yards | 2 Touchdowns

Quenton Nelson | OG

• Injury: Wrist
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 2 Games Played

Anthony Gould | WR

• Injury: Foot
• Practice Status: Did Not Participate In Practice
• 2025 Season Stats: 10 Games Played

Sauce Gardner | CB

• Injury: Calf
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 33 Tackles | 0 Interceptions | 8 Passes Defended

Josh Downs | WR

• Injury: Personal
• Practice Status: Did Not Participate In Practice
• 2025 Receiving Stats: 70 Targets | 47 Receptions | 406 Yards | 4 Touchdowns

DeForest Buckner | DT

• Injury: Neck
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 4.0 Sacks | 9.0 Tackles for Loss | 42 Tackles | 0 Interceptions | 0 Passes Defended

Ameer Abdullah | RB

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 10 Games Played

Daniel Scott | S

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 2 Games Played

49ers vs. Colts Head-to-Head History

• Indianapolis holds a 2-0 record against San Francisco in their last two matchups.
• Over their last two head-to-head matchups, Indianapolis has put up 56 points, while San Francisco has accumulated 41.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Indianapolis Colts

San Francisco 49ers