Colts vs. 49ers Injury Report – Week 16, 2025

Take a look at the injury report for the San Francisco 49ers (10-4), which currently has 12 players listed (including Christian McCaffrey), as the 49ers prepare for their matchup versus the Indianapolis Colts (8-6) at Lucas Oil Stadium, on Monday, Dec. 22 at 8:15 p.m. ET.

Learn more about the San Francisco 49ers vs. the Indianapolis Colts on FOX Sports!

49ers vs. Colts Game Info

• When: Monday, December 22, 2025 at 8:15 p.m. ET
• Where: Lucas Oil Stadium in Indianapolis, Indiana
• TV info: ESPN
• Spread Favorite: 49ers (-4.5)
• Moneyline: 49ers (-225), Colts (+185)
• Total: 46.5 points
• Streaming: FOX One + ESPN Bundle

49ers Injuries

Kurtis Rourke | QB (Out)

• Injury: Knee
• Practice Status: Full Participation in Practice

Ricky Pearsall | WR (Out)

• Injury: Knee
• Practice Status: Did Not Participate In Practice
• 2025 Receiving Stats: 45 Targets | 31 Receptions | 443 Yards | 0 Touchdowns

Renardo Green | CB (Out)

• Injury: Neck
• Practice Status: Limited Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 52 Tackles | 0 Interceptions | 9 Passes Defended

Yetur Gross-Matos | DL (Questionable)

• Injury: Hamstring
• Practice Status: Did Not Participate In Practice

Sam Okuayinonu | DL

• Injury: Ankle
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 2.0 Sacks | 3.0 Tackles for Loss | 31 Tackles | 0 Interceptions | 0 Passes Defended

Christian McCaffrey | RB

• Injury: NIR - Rest
• Practice Status: Full Participation in Practice
• 2025 Rushing: 259 Attempts | 922 Yards | 9 Touchdowns
• 2025 Receiving Stats: 108 Targets | 86 Receptions | 820 Yards | 5 Touchdowns

Jordan Elliott | DL

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 29 Tackles | 0 Interceptions | 0 Passes Defended

Spencer Burford | OL

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 2 Games Played

Tatum Bethune | LB

• Injury: Ankle
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 2.0 Tackles for Loss | 64 Tackles | 0 Interceptions | 1 Pass Defended

Dee Winters | LB

• Injury: Wrist
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 7.0 Tackles for Loss | 89 Tackles | 0 Interceptions | 3 Passes Defended

Trent Williams | OT

• Injury: NIR - Rest
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 5 Games Played

Nickolas Martin | LB

• Injury: Concussion
• Practice Status: Did Not Participate In Practice

Colts Injuries

Bernhard Raimann | OT (Out)

• Injury: Elbow
• Practice Status: Limited Participation in Practice
• 2025 Season Stats: 7 Games Played

Anthony Richardson | QB (Out)

• Injury: Eye
• Practice Status: Limited Participation in Practice

Anthony Gould | WR (Out)

• Injury: Foot
• Practice Status: Did Not Participate In Practice
• 2025 Season Stats: 10 Games Played

Sauce Gardner | CB (Out)

• Injury: Calf
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 33 Tackles | 0 Interceptions | 8 Passes Defended

Daniel Scott | S (Out)

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 2 Games Played

DeForest Buckner | DT

• Injury: Neck
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 4.0 Sacks | 9.0 Tackles for Loss | 42 Tackles | 0 Interceptions | 0 Passes Defended

Germaine Pratt | LB

• Injury: Personal
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 6.0 Tackles for Loss | 108 Tackles | 0 Interceptions | 7 Passes Defended

Tyquan Lewis | DE

• Injury: Chest
• Practice Status: Full Participation in Practice

Alec Pierce | WR

• Injury: Achilles
• Practice Status: Full Participation in Practice
• 2025 Receiving Stats: 68 Targets | 39 Receptions | 785 Yards | 2 Touchdowns

Quenton Nelson | OG

• Injury: Wrist
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 2 Games Played

Johnathan Edwards | CB

• Injury: Illness
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 20 Tackles | 0 Interceptions | 3 Passes Defended

Josh Downs | WR

• Injury: Personal
• Practice Status: Full Participation in Practice
• 2025 Receiving Stats: 70 Targets | 47 Receptions | 406 Yards | 4 Touchdowns

Ameer Abdullah | RB

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 10 Games Played

Zaire Franklin | LB

• Injury: NIR - Rest
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 2.0 Sacks | 5.0 Tackles for Loss | 104 Tackles | 0 Interceptions | 4 Passes Defended

Samson Ebukam | DE

• Injury: NIR - Rest
• Practice Status: Limited Participation in Practice
• 2025 Defensive Stats: 2.0 Sacks | 4.0 Tackles for Loss | 22 Tackles | 0 Interceptions | 0 Passes Defended

Grover Stewart | DT

• Injury: Rest
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.5 Sacks | 5.0 Tackles for Loss | 47 Tackles | 1 Interception | 4 Passes Defended

49ers vs. Colts Head-to-Head History

• Indianapolis has a 2-0 record against San Francisco in their last two matchups.
• Over their last two head-to-head contests, Indianapolis has racked up 56 points, while San Francisco has tallied 41.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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