Chargers vs. Titans 2025 Prediction, Odds, Picks - Nov 2

The Los Angeles Chargers (5-3) are heavy favorites (-10.5) over the Tennessee Titans (1-7). The Titans have lost three games straight. The expected point total for the matchup is set at 44.5.

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Chargers vs. Titans Odds & Betting Lines

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Chargers vs. Titans Prediction & Pick

• Pick ATS: Titans (+10.5)
  
• Pick OU: Under (44.5)
  
• Prediction: Chargers 26 - Titans 18

How to Watch Los Angeles vs. Tennessee

• Game date: Sunday, November 2, 2025
• Time: 1 p.m. ET
• Venue: Nissan Stadium
• Location: Nashville, Tennessee
• TV: CBS
• Live Boxscore: FOX Sports

Chargers vs. Titans Recent Matchups

• In their past five head-to-head contests, Los Angeles has beaten Tennessee three times.
• In their last five head-to-head matchups, Los Angeles has compiled 108 points against Tennessee, while giving up only 100 points.

Los Angeles Betting Info

• Los Angeles is 4-4-0 against the spread this year.
• Los Angeles contests this year have hit the over 50% of the time (four times in eight games with a set point total).
• When playing as the moneyline favorite, the Chargers are 4-3 (winning 57.1% of the time).
• The implied probability in this matchup, considering the moneyline, gives the Chargers an 86.6% chance to win.

Chargers Stats

Los Angeles' Key Players

Offense

• Justin Herbert has 2,140 passing yards (first in the NFL), 16 touchdowns (third in the NFL) and seven interceptions this year. He has completed 67.9% of his attempts, averaging 267.5 yards per game and 7.2 per attempt.
• In addition to his passing stats, Herbert also has 248 rushing yards (third on the Chargers), but no touchdowns.
• Keenan Allen's 479 receiving yards this season have come from 70 targets and 48 receptions (eighth in the NFL). He's averaging 59.9 receiving yards and six catches per game, with four receiving touchdowns.
• In six games played, Quentin Johnston is averaging 67.8 yards and 4.7 receptions per game to total 407 receiving yards and 28 catches. He's been targeted 47 times, and has five receiving touchdowns (eighth in the NFL).
• Ladd McConkey has 468 receiving yards and three touchdowns with 43 catches on 68 targets. He is averaging 5.4 receptions and 58.5 yards per game.

Defense

• On defense, Tuli Tuipulotu has 22 tackles, nine TFL, six sacks, and two passes defended in 2025.
• Derwin James has picked off one pass and has added 49 tackles, five TFL, 1.5 sacks, and three passes defended.
• Daiyan Henley has put up 52 tackles, three TFL, two sacks, and one interception this year. He leads the Chargers in tackles.
• Troy Dye has one sack as well as four TFL and 39 tackles on the season.

Tennessee Betting Info

• Tennessee has registered a win-loss record of 2-6-0 against the spread this season.
• The Titans have yet to cover the spread this year when underdogs by 10.5 points or more.
• Tennessee's games have finished with a final combined score above the over/under five times this season.
• The Titans have been underdogs in eight games this season and won one (12.5%) of those contests.
• The implied probability of a win by the Titans based on the moneyline is 17.5%.

Titans Stats

Tennessee's Key Players

Offense

• Cameron Ward has passed for 1,615 yards this year, with five touchdowns and six interceptions. He is completing 57.7% of his attempts while averaging 201.9 yards per game and 5.9 per attempt.
• Tony Pollard has scored two rushing touchdowns, while totaling 424 rushing yards (3.9 per carry and 53 per game).
• Pollard has added 18 receptions (2.3 per game) for 131 yards (16.4 per game), without a receiving touchdown. He's been targeted 22 times in the passing attack.
• This season, Elic Ayomanor has caught 23 passes for 277 receiving yards with two touchdowns through the air. He has been targeted 47 total times and is averaging 2.9 receptions per game over eight games played.
• Calvin Ridley has 16 catches for 290 yards without a receiving touchdown. He averages 2.7 yards per game through six games and has been targeted 35 times.

Defense

• Cedric Gray has recorded four TFL and 71 tackles over eight games in 2025.
• Jeffery Simmons' stat sheet includes 30 tackles, eight TFL, and 4.5 sacks.
• In the 2025 season, Amani Hooker has 41 tackles, two TFL, and one sack in eight games.
• Cody Barton has totaled two TFL, 45 tackles, and two interceptions.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Tennessee Titans

Los Angeles Chargers